Spiritual Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Department of Nursing, Faculty of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Indian J Gastroenterol. 2020 Oct;39(5):419-425. doi: 10.1007/s12664-020-01046-7. Epub 2020 Dec 1.
Patients with type 1 diabetes mellitus (T1DM) are at high risk for celiac disease (CD) due to the common genetic background and interaction between environmental and immunological factors. The purpose of this systematic review and meta-analysis was to estimate the prevalence of CD among Iranian patients with type 1 diabetes. The search for articles was conducted using the following keywords: "celiac disease," "celiac," "coeliac disease," "diabetes," "Iran," and all other possible combinations of these terms. The following databases were searched from inception to June 2019: Scientific Information Database (SID), MagIran, Web of Science, PubMed, and Scopus. Meta-analysis was performed using the random-effects models, and the heterogeneity of results across the studies was assessed using the Cochran's Q test and quantified by the I statistic. Data analysis was performed by Stata version 14. A total of 14 papers were included in the meta-analysis, involving 2030 Iranian patients with T1DM. The pooled prevalence of CD in patients with T1DM was 5% (95% CI 3-7). The prevalence of CD in Tehran (4%; 95% CI 1-6) was lower than in other provinces of the country (6%; 95% CI 4-8). Meta-regression analysis showed that, with increasing sample size, the prevalence of CD was significantly reduced (p = 0.018).Given the adverse effects of CD , such as osteoporosis and malignancy (especially lymphoma), patients with T1DM must be screened for CD .
1 型糖尿病（T1DM）患者由于共同的遗传背景和环境与免疫因素之间的相互作用，患乳糜泻（CD）的风险很高。本系统评价和荟萃分析的目的是估计伊朗 1 型糖尿病患者中 CD 的患病率。使用以下关键词搜索文章：“乳糜泻”、“乳糜泻”、“乳糜泻”、“糖尿病”、“伊朗”以及这些术语的所有其他可能组合。从成立到 2019 年 6 月，在以下数据库中搜索：科学信息数据库（SID）、MagIran、Web of Science、PubMed 和 Scopus。使用随机效应模型进行荟萃分析，使用 Cochran's Q 检验评估研究之间结果的异质性，并通过 I 统计量量化。数据分析使用 Stata 版本 14。共有 14 篇论文被纳入荟萃分析，涉及 2030 名伊朗 1 型糖尿病患者。1 型糖尿病患者中 CD 的总患病率为 5%（95%CI 3-7）。德黑兰（4%；95%CI 1-6）的 CD 患病率低于该国其他省份（6%；95%CI 4-8）。元回归分析表明，随着样本量的增加，CD 的患病率显著降低（p=0.018）。鉴于 CD 的不良影响，如骨质疏松症和恶性肿瘤（尤其是淋巴瘤），1 型糖尿病患者必须进行 CD 筛查。
