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儿童多系统炎症综合征（MIS-C）和轻度及重度 2019 冠状病毒病（COVID-19）患儿的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）抗体反应。

Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19).

机构信息

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

出版信息

J Pediatric Infect Dis Soc. 2021 May 28;10(5):669-673. doi: 10.1093/jpids/piaa161.

DOI:10.1093/jpids/piaa161
PMID:33263756
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7799010/
Abstract

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.

摘要

儿童严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）抗体反应仍知之甚少。在这里，我们表明患有儿童多系统炎症综合征（MIS-C）的儿科患者的 SARS-CoV-2 刺突免疫球蛋白 G（IgG）滴度高于患有严重 2019 年冠状病毒病（COVID-19）的患者，这可能反映了 MIS-C 患者感染后时间更长。