Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
Curr Oncol Rep. 2020 Dec 2;23(1):7. doi: 10.1007/s11912-020-00990-z.
Along with population aging, the incidence of both heart failure (HF) and cancer is increasing. However, little is known about new-onset cancer in HF patients. This review aims at showing recent discoveries concerning this subset of patients.
Not only cancer and HF share similar risk factors but also HF itself can stimulate cancer development. Some cytokines produced by the failing heart induce mild inflammation promoting carcinogenesis, as it has been recently suggested by an experimental model of HF in mice. The incidence of new-onset cancer is higher in HF patients compared to the general population, and it significantly worsens their prognosis. Moreover, the management of HF patients developing new-onset cancer is challenging, especially due to the limited therapeutic options for patients affected by both cancer and HF and the higher risk of cardiotoxicity from anticancer drugs.
随着人口老龄化，心力衰竭（HF）和癌症的发病率都在增加。然而，HF 患者新发癌症的情况知之甚少。本综述旨在展示有关这部分患者的最新发现。
不仅癌症和 HF 有相似的危险因素，HF 本身也可以刺激癌症的发展。衰竭心脏产生的一些细胞因子引起轻微炎症，促进致癌作用，最近一项 HF 小鼠实验模型提示了这一点。与一般人群相比，HF 患者新发癌症的发生率更高，并且显著恶化了他们的预后。此外，HF 患者新发癌症的治疗具有挑战性，特别是因为同时患有癌症和 HF 的患者的治疗选择有限，以及抗癌药物的心脏毒性风险更高。
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