Qu Bingjie, Xu Qiaochu, Yuan Linxi, Chen Ying
Wisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Life (Basel). 2025 May 22;15(6):832. doi: 10.3390/life15060832.
Mineral elements are essential for human health. Our previous study identified distinct clusters of health-related mineral elements in surface soil among different regions and demonstrated an association between these clusters and health profiles in the USA. The present study further explores the relationship between these mineral clusters and mortality from detailed specific types of cancers and cardiovascular diseases by using county-level data from 3080 counties across the USA. Utilizing multivariate regression models with adjustment for socio-demographic and geographical factors, our analysis of county-level data revealed that residents in the regions of 'infertile' cluster have higher mortality rates for most types of cancers (18/29) and cardiovascular conditions (4/10) compared with people who live elsewhere. Notably, this relationship is pronounced for several specific leading causes of death such as tracheal, bronchus, lung cancer (regression coefficient (99.5% CIs), 6.29 (4.46, 8.13)), prostate cancer (1.06 (0.53, 1.6)), cerebrovascular disease (3.15 (1.74, 4.55)), and hypertensive heart disease (1.23 (0.23, 2.23)). Our findings highlight the critical role of soil minerals in human health and underscore the need for integrating geochemical data in public health strategies and environmental management policies.
矿物质元素对人体健康至关重要。我们之前的研究确定了不同地区表层土壤中与健康相关的矿物质元素的不同聚类，并证明了这些聚类与美国的健康状况之间存在关联。本研究通过使用来自美国3080个县的县级数据，进一步探讨了这些矿物质聚类与特定详细类型癌症和心血管疾病死亡率之间的关系。利用多变量回归模型对社会人口统计学和地理因素进行调整，我们对县级数据的分析显示，与其他地区的居民相比，“贫瘠”聚类地区的居民在大多数类型的癌症（29种中的18种）和心血管疾病（10种中的4种）方面的死亡率更高。值得注意的是，这种关系在几种特定的主要死因中尤为明显，如气管、支气管、肺癌（回归系数（99.5%置信区间），6.29（4.46，8.13））、前列腺癌（1.06（0.53，1.6））、脑血管疾病（3.15（1.74，4.55））和高血压性心脏病（1.23（0.23，2.23））。我们的研究结果突出了土壤矿物质在人类健康中的关键作用，并强调了将地球化学数据纳入公共卫生战略和环境管理政策的必要性。
