Sonkodi S, Sohár I, Stumpf E
First Department of Medicine, University Medical School, Szeged, Hungary.
Acta Physiol Hung. 1987;70(4):403-7.
Goldblatt hypertension was induced in rats by constricting the renal artery on one side. In one group of animals the contralateral kidney remained untouched (two-kidney hypertension), while in the other it was removed (one-kidney hypertension). In the two-kidney hypertension group, renin activity was higher than in the control animals, the fibrinogen was normal both in arterial and venous blood while in one-kidney hypertension the PRA was normal, but the fibrinogen was increased. A close significant correlation could be demonstrated between blood pressure and fibrinogen.
通过单侧肾动脉狭窄在大鼠中诱发肾血管性高血压。在一组动物中，对侧肾脏未受影响（双肾性高血压），而在另一组中，对侧肾脏被切除（单肾性高血压）。在双肾性高血压组中，肾素活性高于对照动物，动脉血和静脉血中的纤维蛋白原均正常，而在单肾性高血压中，血浆肾素活性正常，但纤维蛋白原增加。血压与纤维蛋白原之间可证明存在密切的显著相关性。
