Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
Clin Immunol. 2021 Jan;222:108636. doi: 10.1016/j.clim.2020.108636. Epub 2020 Nov 29.
Symptomatic dermographism (SD) is the most common form of physical urticaria. So far no promising serum biomarkers for SD have been reported. Recently, microRNAs (miRNAs) have been reported to be serum biomarkers for chronic spontaneous urticaria. However, association of miRNAs with SD remains unclear. We enrolled 55 SD patients and 52 healthy controls in this study. We found that serum expressions of miR-126-3p and miR-16-5p were significantly downregulated in active SD patients and upregulated in remission. The area under the curve values of miR-126-3p (0.769) and miR-16-5p (0.789) showed significant ability to diagnostic SD. Serum level of vascular endothelial growth factor (VEGF)-A, a known target of the two miRNAs, was significantly increased in active SD patients and decreased in remission. Moreover, serum VEGF-A level was inversely correlated with expressions of miR-126-3p and miR-16-5p. Our findings indicate that miR-126-3p and miR-16-5p can serve as potential serum biomarkers for SD.
症状性皮肤划痕症（SD）是最常见的物理性荨麻疹形式。到目前为止，尚未报道有前景的 SD 血清生物标志物。最近，microRNAs（miRNAs）已被报道为慢性自发性荨麻疹的血清生物标志物。然而，miRNAs 与 SD 的关联尚不清楚。我们在这项研究中招募了 55 名 SD 患者和 52 名健康对照者。我们发现，活跃的 SD 患者血清 miR-126-3p 和 miR-16-5p 的表达显著下调，而缓解期则上调。miR-126-3p（0.769）和 miR-16-5p（0.789）的曲线下面积值显示出对 SD 的诊断能力显著。两种 miRNA 的已知靶标血管内皮生长因子（VEGF）-A 的血清水平在活跃的 SD 患者中显著增加，在缓解期降低。此外，血清 VEGF-A 水平与 miR-126-3p 和 miR-16-5p 的表达呈负相关。我们的研究结果表明，miR-126-3p 和 miR-16-5p 可以作为 SD 的潜在血清生物标志物。
