Magnifico Irene, Petronio Petronio Giulio, Venditti Noemi, Cutuli Marco Alfio, Pietrangelo Laura, Vergalito Franca, Mangano Katia, Zella Davide, Di Marco Roberto
Department of Health and Medical Sciences "V. Tiberio" Università degli Studi del Molise, 8600 Campobasso, Italy.
Department of Agricultural, Environmental and Food Sciences (DiAAA), Università degli Studi del Molise, 86100 Campobasso, Italy.
Pharmaceuticals (Basel). 2020 Nov 22;13(11):411. doi: 10.3390/ph13110411.
Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be considered as the two main factors involved in this pathological skin condition. The loss of the skin barrier function is often linked to dysbiosis and immunological dysfunction, with an imbalance in the ratio between the pathogen and/or other microorganisms residing in the skin. The bibliographic research was conducted on PubMed, using the following keywords: 'atopic dermatitis', 'bacterial therapy', 'drug delivery system' and 'alternative therapy'. The main studies concerning microbial therapy, such as the use of bacteria and/or part thereof with microbiota transplantation, and drug delivery systems to recover skin barrier function have been summarized. The studies examined show great potential in the development of effective therapeutic strategies for AD and AD-like symptoms. Despite this promise, however, future investigative efforts should focus both on the replication of some of these studies on a larger scale, with clinical and demographic characteristics that reflect the general AD population, and on the process of standardisation, in order to produce reliable data.
特应性皮炎（AD）是一种病因机制复杂、难以完全理解的病理性皮肤病。科学证据表明，在所有病因中，皮肤屏障受损、皮肤微生物群失调以及免疫功能障碍可被视为与这种病理性皮肤病相关的两个主要因素。皮肤屏障功能的丧失通常与微生物群失调和免疫功能障碍有关，皮肤中病原体和/或其他微生物的比例失衡。在PubMed上进行了文献研究，使用了以下关键词：“特应性皮炎”、“细菌疗法”、“药物递送系统”和“替代疗法”。总结了有关微生物疗法的主要研究，例如使用细菌和/或其部分进行微生物群移植，以及恢复皮肤屏障功能的药物递送系统。所审查的研究在开发针对AD和类AD症状的有效治疗策略方面显示出巨大潜力。然而，尽管有此前景，未来的研究工作应既侧重于对其中一些研究进行更大规模的重复，使其临床和人口统计学特征反映一般AD人群，又侧重于标准化过程，以便产生可靠的数据。
