Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Janssen Research and Development, Spring House, Pennsylvania, USA.
J Invest Dermatol. 2021 Feb;141(2):274-284. doi: 10.1016/j.jid.2020.07.006. Epub 2020 Sep 15.
Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.
特应性皮炎（AD）是一种常见的慢性炎症性皮肤病，其特征是反复发作的瘙痒性皮疹。多种因素导致 AD 的发病机制，包括皮肤屏障功能障碍、微生物失调和免疫失调。这些因素之间的相互作用形成了一个复杂的、多向的网络，可以加重特应性皮肤病，但也可以通过靶向治疗来改善。本文综述了 AD 中致病因素之间的复杂相互作用及其对疾病发展和治疗干预的影响。
