Björkholm B, Granström M, Wahl M, Hedström C E, Hagberg L
Department of Infectious Diseases, Ostra sjukhuset, Göteborg, Sweden.
Eur J Clin Microbiol. 1987 Dec;6(6):637-40. doi: 10.1007/BF02013059.
Booster doses of 3 Lf or 7.5 Lf of a regular diphtheria vaccine were given to 200 previously immunized adult volunteers. The toxoid was prepared from toxin with a purity of 2100 Lf/mg protein nitrogen and adsorbed to aluminium phosphate. Systemic reactions were rare and no severe symptoms were observed. Local reactions occurred in 40-50% of the vaccinees, but in only 7.5% were they of clinical significance, i.e. an area of redness/swelling greater than 5 cm. The two doses did not cause significant differences in reaction rates, and the 7.5 Lf dose elicited a better antitoxin response. Thus, a dose of 7.5 Lf diphtheria toxoid of similar purity can safely be given to adults in vaccines.
给200名先前已免疫的成年志愿者接种了3Lf或7.5Lf常规白喉疫苗的加强剂量。类毒素由纯度为2100Lf/mg蛋白氮的毒素制备而成，并吸附于磷酸铝。全身反应罕见，未观察到严重症状。40% - 50%的接种者出现局部反应，但只有7.5%具有临床意义，即红肿面积大于5厘米。这两种剂量在反应率上没有显著差异，7.5Lf剂量引发了更好的抗毒素反应。因此，纯度相似的7.5Lf白喉类毒素剂量可安全地用于成人疫苗接种。
