Feery B J, Benenson A S, Forsyth J R, Menser M A, Minty D W
Med J Aust. 1981 Feb 7;1(3):128-30. doi: 10.5694/j.1326-5377.1981.tb135382.x.
A study was undertaken in Schick-positive university students and schoolchildren to determine the diphtheria antitoxin response to vaccines containing a reduced dose of adsorbed diphtheria toxoid. It was found that the majority of participants, apparently previously sensitized, responded with an increase in antitoxin titre to protective levels after performance of the Schick test, or after the first dose of vaccine. A group of non-immune students required three doses of vaccine to reach adequate antitoxin levels to ensure durable immunity. Only one local reaction was observed in the group of 51 students, and this was attributed to an Arthus-type reaction involving the tetanus toxoid component of a combined adsorbed diphtheria and tetanus vaccine.
对锡克试验阳性的大学生和学童进行了一项研究，以确定他们对白喉类毒素剂量降低的疫苗的白喉抗毒素反应。结果发现，大多数参与者显然先前已致敏，在进行锡克试验后或接种第一剂疫苗后，抗毒素滴度升高至保护水平。一组无免疫力的学生需要接种三剂疫苗才能达到足够的抗毒素水平以确保持久免疫。在51名学生的组中仅观察到1例局部反应，这归因于涉及吸附白喉和破伤风联合疫苗中破伤风类毒素成分的阿瑟斯型反应。
