Xu Peipei, Wang Yunhua
PET/CT Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Oct 28;45(10):1255-1260. doi: 10.11817/j.issn.1672-7347.2020.190151.
Small cell lung cancer belongs to neuroendocrine tumors and is the most malignant one in lung cancer. It possesses clinical features such as rapid growth, easy early metastasis, and poor prognosis. PET/CT is a molecular imaging technique that combines morphological and metabolic imaging. It has been widely used in the diagnosis, staging, treatment planning, efficacy and prognosis evaluation of tumors. This article reviews the efficacy, prognostic parameters, evaluation criteria, possible influencial factors, clinical application and value of F-fluorodeoxyglucose (F-FDG) PET/CT in small cell lung cancer. The accuracy and sensitivity of F-FDG PET/CT in small cell lung cancer stage, efficacy and prognosis evaluation are significantly higher than those of traditional imaging methods. Maximal standardized uptake, metabolic tumor volume, and total lesion glycolysis have been applied in efficacy and prognosis prediction, which have important value in developing the personalized treatment and improving the survival for small cell lung cancer patient.
小细胞肺癌属于神经内分泌肿瘤，是肺癌中恶性程度最高的一种。它具有生长迅速、早期易转移、预后差等临床特点。PET/CT是一种将形态学和代谢成像相结合的分子成像技术。它已广泛应用于肿瘤的诊断、分期、治疗方案制定、疗效及预后评估。本文综述了氟脱氧葡萄糖（F-FDG）PET/CT在小细胞肺癌中的疗效、预后参数、评估标准、可能的影响因素、临床应用及价值。F-FDG PET/CT在小细胞肺癌分期、疗效及预后评估中的准确性和敏感性显著高于传统成像方法。最大标准化摄取值、代谢肿瘤体积和总病变糖酵解已应用于疗效和预后预测，对制定小细胞肺癌患者的个体化治疗方案及提高生存率具有重要价值。
