Dermatology, Andrology and Venereology, Qena Faculty of Medicine, South Valley University, Qena, 83523, Egypt.
Department of Dermatology, Andrology and Venereology, Aswan Faculty of Medicine, Aswan University, Tingar, Egypt.
Sci Rep. 2020 Dec 2;10(1):21000. doi: 10.1038/s41598-020-77968-1.
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. There are a lot of evidences on the importance of vitamin D and house dust mite (HDM) allergens in the etiology and course of AD. The objectives of this study are to evaluate the relation between vitamin D3 level and house dust mites (HDM) Dermatophagoidspecies sensitization in pathogenesis of atopic dermatitis. Cross-sectional design study was conducted on 50 atopic dermatitis patients. Blood analysis were done to determine level of vitamin D3, total IgE by fluorescent immunoassay & specific IgE for HDM (d1, d2) & other inhalant allergens by ELISA test. There was significant high negative correlation with the specific IgE for HDM (r = -0. 62, p < 0.001) and vitamin D3. & there was non-significant minimal negative correlation with the specific IgE and other inhalant allergens (r = - 0.10, p > 0.05). There was a statistically significant relation between level of vitamin D3 and atopic dermatitis severity and sensitization to HDM and other allergens.
特应性皮炎（AD）是一种慢性复发性炎症性皮肤病。有大量证据表明维生素 D 和屋尘螨（HDM）过敏原在 AD 的发病机制和病程中起重要作用。本研究旨在评估维生素 D3 水平与屋尘螨（HDM）致敏在特应性皮炎发病机制中的关系。对 50 例特应性皮炎患者进行了横断面设计研究。通过荧光免疫分析测定血液中维生素 D3、总 IgE 的水平，通过 ELISA 试验测定特异性 IgE 对 HDM（d1、d2）和其他吸入性过敏原的水平。特异性 IgE 对 HDM（r = -0.62，p < 0.001）和维生素 D3 呈显著负相关，与特异性 IgE 和其他吸入性过敏原呈低度负相关（r = -0.10，p > 0.05）。维生素 D3 水平与特应性皮炎严重程度以及对 HDM 和其他过敏原的致敏之间存在统计学显著关系。
