Cankurt Tayyar, Celik İbrahim E, Ozturk Selcuk, Maden Orhan
Cardiology Clinic, Amasya University Sabuncuoglu Sereefeddin State Hospital, Ankara, Turkey.
Department of Cardiology, University of Health Sciences, Ankara Education and Research Hospital, Ankara, Turkey.
Int J Angiol. 2020 Dec;29(4):237-244. doi: 10.1055/s-0040-1714751. Epub 2020 Aug 30.
The study aimed to evaluate the inflammatory blood parameters in acute coronary syndrome (ACS) patients with a history of coronary artery bypass graft (CABG) and treated with percutaneous coronary intervention (PCI) of saphenous vein graft (SVG). A total of 347 patients who underwent urgent SVG PCI with the diagnosis of ACS were included in the study. After the application of exclusion criteria, 79 patients were allocated into two groups, namely, successful PCI ( = 59) and unsuccessful PCI ( = 20), and included in the statistical analysis. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels were significantly higher in patients with unsuccessful SVG PCI. In the logistic regression analysis, PLR, C-reactive protein, and diabetes mellitus emerged as independent factors associated with unsuccessful SVG PCI. The area under the curve for PLR was 0.70 (95% confidence interval: 0.55-0.85, = 0.006). The cut-off value of PLR (128.99) was associated with 70.0% sensitivity and 69.5% specificity. Elevated inflammatory status is associated with unsuccessful PCI of SVG in ACS patients. Increased PLR levels on admission is an independent predictor of this situation. This cheap and simple marker can help us to predict unsuccessful SVG PCI in ACS patients.
本研究旨在评估有冠状动脉旁路移植术(CABG)病史且接受大隐静脉桥血管(SVG)经皮冠状动脉介入治疗(PCI)的急性冠状动脉综合征(ACS)患者的血液炎症参数。共有347例诊断为ACS并接受紧急SVG PCI的患者纳入本研究。应用排除标准后,79例患者被分为两组,即PCI成功组(n = 59)和PCI失败组(n = 20),并纳入统计分析。SVG PCI失败患者的中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)水平显著更高。在逻辑回归分析中,PLR、C反应蛋白和糖尿病是与SVG PCI失败相关的独立因素。PLR的曲线下面积为0.70(95%置信区间:0.55 - 0.85,P = 0.006)。PLR的截断值(128.99)与70.0%的敏感性和69.5%的特异性相关。炎症状态升高与ACS患者SVG PCI失败相关。入院时PLR水平升高是这种情况的独立预测因素。这个廉价且简单的标志物可帮助我们预测ACS患者SVG PCI失败。