Boey Timothy, Sule Ashita Ashish, Sule Ashish Anil
Anglo-Chinese Junior College, Singapore.
Raffles Girl's School (Secondary), Singapore.
Int J Angiol. 2020 Dec;29(4):256-259. doi: 10.1055/s-0039-1694780. Epub 2019 Aug 7.
This case report aims to highlight a successful example of using novel oral anticoagulants (NOACs), such as apixaban, to prevent recurrent venous thromboembolism (VTE) in patients with solid-organ malignancy, as an alternative to low-molecular weight heparin (LMWH). Discussed is the case of a 67-year-old woman diagnosed with recurrent thrombosis in the upper-right limb and malignancy of right breast with metastasis to the axillary lymph nodes. Over a follow-up period of more than 1 year, there was no recurrence of VTE and D-dimer decreased, illuminating the possibility of apixaban as an alternative form of treatment for recurrent VTE in patients with malignancy. This appears to be one of the first case reports in Singapore.
本病例报告旨在突出一个成功案例，即使用新型口服抗凝剂（NOACs），如阿哌沙班，作为低分子量肝素（LMWH）的替代药物，来预防实体器官恶性肿瘤患者的复发性静脉血栓栓塞（VTE）。本文讨论了一名67岁女性的病例，该患者被诊断为右上肢复发性血栓形成以及右乳恶性肿瘤伴腋窝淋巴结转移。在超过1年的随访期内，VTE未复发且D - 二聚体水平下降，这表明阿哌沙班有可能作为恶性肿瘤患者复发性VTE的一种替代治疗方式。这似乎是新加坡首批病例报告之一。
