Yang Ya, Zhao Yalei, Zhang Fen, Zhang Lingjian, Li Lanjuan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Aging Dis. 2020 Dec 1;11(6):1481-1495. doi: 10.14336/AD.2020.0903. eCollection 2020 Dec.
Coronavirus disease 2019 (COVID-19) is causing problems worldwide. Most people are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but elderly populations are more susceptible. Elevated susceptibility and death rates in elderly COVID-19 patients, especially those with age-related complications, are challenges for pandemic prevention and control. In this paper, we review the clinical features of elderly patients with COVID-19 and explore the related molecular mechanisms that are essential for the exploration of preventive and therapeutic strategies in the current pandemic. Furthermore, we analyze the feasibility of currently recommended potential novel methods against COVID-19 among elderly populations.
2019冠状病毒病（COVID-19）正在全球引发问题。大多数人对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）易感，但老年人群更易感。老年COVID-19患者，尤其是那些有与年龄相关并发症的患者，其易感性和死亡率升高，是疫情防控面临的挑战。在本文中，我们回顾了老年COVID-19患者的临床特征，并探讨了相关分子机制，这些机制对于探索当前疫情中的预防和治疗策略至关重要。此外，我们分析了目前推荐的针对COVID-19的潜在新方法在老年人群中的可行性。
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