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第三次接种麻疹-腮腺炎-风疹疫苗后抗体反应的动态变化表明，与第二次接种相比，抗体下降速度更慢。

Dynamics of the Antibody Response After a Third Dose of Measles-Mumps-Rubella Vaccine Indicate a Slower Decline Compared With a Second Dose.

作者信息

Kaaijk Patricia, Nicolaie M Alina, van Rooijen Debbie, van Houten Marianne A, van der Klis Fiona R, Buisman Anne-Marie, van Binnendijk Rob S

机构信息

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Spaarne Gasthuis Academy, Hoofddorp, the Netherlands.

出版信息

Open Forum Infect Dis. 2020 Oct 20;7(11):ofaa505. doi: 10.1093/ofid/ofaa505. eCollection 2020 Nov.

DOI:10.1093/ofid/ofaa505
PMID:33269296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7686655/
Abstract

BACKGROUND

Breakthrough infections of measles and mumps have raised concerns about the duration of vaccine-induced immunity, which might be improved by a third dose of measles-mumps-rubella vaccine (MMR3).

METHODS

Here we compared (IgG) antibody levels against measles, mumps, and rubella in blood samples of 9-year-old children and young adults (18-25 years) following MMR2 and MMR3, respectively.

RESULTS

We found that, in addition to antibody boosting for all 3 vaccine components, MMR3 resulted in lower antibody decay rates than MMR2; the declines were most prominent for mumps and rubella.

CONCLUSIONS

This study suggests that MMR3 provides long-lasting seroprotection against measles, mumps, and rubella.

摘要

背景

麻疹和腮腺炎突破性感染引发了对疫苗诱导免疫持续时间的担忧，而麻疹-腮腺炎-风疹三联疫苗第三剂（MMR3）可能会改善这一情况。

方法

在此，我们分别比较了9岁儿童和年轻成年人（18 - 25岁）在接种MMR2和MMR3后血液样本中针对麻疹、腮腺炎和风疹的（IgG）抗体水平。

结果

我们发现，除了对所有三种疫苗成分的抗体增强作用外，MMR3导致的抗体衰减率低于MMR2；腮腺炎和风疹的下降最为显著。

结论

本研究表明，MMR3可提供针对麻疹、腮腺炎和风疹的长期血清保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/266d/7686655/37d055ca8341/ofaa505_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/266d/7686655/438ca5b68564/ofaa505_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/266d/7686655/37d055ca8341/ofaa505_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/266d/7686655/438ca5b68564/ofaa505_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/266d/7686655/37d055ca8341/ofaa505_fig2.jpg

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