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Optimizing the Translational Value of Mouse Models of ALS for Dysphagia Therapeutic Discovery.优化肌萎缩侧索硬化症（ALS）小鼠模型的转化价值，以促进吞咽障碍治疗的发现。
Dysphagia. 2020 Apr;35(2):343-359. doi: 10.1007/s00455-019-10034-9. Epub 2019 Jul 12.
2
Combined respiratory training in an individual with C9orf72 amyotrophic lateral sclerosis.对一名患有C9orf72型肌萎缩侧索硬化症的个体进行联合呼吸训练。
Ann Clin Transl Neurol. 2018 Aug 21;5(9):1134-1138. doi: 10.1002/acn3.623. eCollection 2018 Sep.
3
Hypoglossal Motor Neuron Death Via Intralingual CTB-saporin (CTB-SAP) Injections Mimic Aspects of Amyotrophic Lateral Sclerosis (ALS) Related to Dysphagia.舌下运动神经元通过舌内 CTB-saporin（CTB-SAP）注射死亡模拟与吞咽困难相关的肌萎缩侧索硬化症（ALS）的某些方面。
Neuroscience. 2018 Oct 15;390:303-316. doi: 10.1016/j.neuroscience.2018.08.026. Epub 2018 Sep 1.
4
Impact of expiratory strength training in amyotrophic lateral sclerosis: Results of a randomized, sham-controlled trial.呼气力量训练对肌萎缩侧索硬化症的影响：一项随机、假对照试验的结果。
Muscle Nerve. 2019 Jan;59(1):40-46. doi: 10.1002/mus.26292. Epub 2018 Nov 29.
5
Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death.胸膜内注射霍乱毒素B亚单位-皂草素诱导呼吸运动神经元死亡后的膈神经长期易化
Respir Physiol Neurobiol. 2018 Oct;256:43-49. doi: 10.1016/j.resp.2017.08.003. Epub 2017 Aug 16.
6
Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review.描述运动神经元疾病（MND）吞咽困难的研究文献趋势：一项范围综述
Dysphagia. 2017 Dec;32(6):734-747. doi: 10.1007/s00455-017-9819-x. Epub 2017 Jun 29.
7
Age-related effect of cell death on fiber morphology and number in tongue muscle.细胞死亡对舌肌纤维形态和数量的年龄相关影响。
Muscle Nerve. 2018 Jan;57(1):E29-E37. doi: 10.1002/mus.25671. Epub 2017 May 16.
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Acta Histochem. 2016 Jul;118(6):581-587. doi: 10.1016/j.acthis.2016.06.003. Epub 2016 Jun 28.
9
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10
The Biology of Long-Term Denervated Skeletal Muscle.长期去神经支配骨骼肌的生物学
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舌和舌下神经形态学后舌内霍乱毒素 B 链霉素注射。

Tongue and hypoglossal morphology after intralingual cholera toxin B-saporin injection.

机构信息

Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA.

Department of Otolaryngology-Head and Neck Surgery, University of Missouri, Columbia, Missouri, USA.

出版信息

Muscle Nerve. 2021 Mar;63(3):413-420. doi: 10.1002/mus.27131. Epub 2020 Dec 15.

DOI:10.1002/mus.27131
PMID:33269488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117177/
Abstract

INTRODUCTION

We recently developed an inducible model of dysphagia using intralingual injection of cholera toxin B conjugated to saporin (CTB-SAP) to cause death of hypoglossal neurons. In this study we aimed to evaluate tongue morphology and ultrastructural changes in hypoglossal neurons and nerve fibers in this model.

METHODS

Tissues were collected from 20 rats (10 control and 10 CTB-SAP animals) on day 9 post-injection. Tongues were weighed, measured, and analyzed for microscopic changes using laminin immunohistochemistry. Hypoglossal neurons and axons were examined using transmission electron microscopy.

RESULTS

The cross-sectional area of myofibers in the posterior genioglossus was decreased in CTB-SAP-injected rats. Degenerative changes were observed in both the cell bodies and distal axons of hypoglossal neurons.

DISCUSSION

Preliminary results indicate this model may have translational application to a variety of neurodegenerative diseases resulting in tongue dysfunction and associated dysphagia.

摘要

简介

我们最近开发了一种使用霍乱毒素 B 与相思豆毒素（CTB-SAP）连接物进行舌内注射的吞咽困难诱导模型，以导致舌下神经元死亡。在这项研究中，我们旨在评估该模型中舌下神经元和神经纤维的舌形态和超微结构变化。

方法

在注射后第 9 天，从 20 只大鼠（10 只对照和 10 只 CTB-SAP 动物）中收集组织。测量舌的重量、长度，并使用层粘连蛋白免疫组织化学分析微观变化。使用透射电子显微镜检查舌下神经元和轴突。

结果

注射 CTB-SAP 的大鼠的后颏舌肌肌纤维的横截面积减小。舌下神经元的胞体和远侧轴突均观察到退行性变化。

讨论

初步结果表明，该模型可能具有向多种导致舌功能障碍和相关吞咽困难的神经退行性疾病转化的应用潜力。