Department of Pharmacognosy, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina.
Med Glas (Zenica). 2021 Feb 1;18(1):47-54. doi: 10.17392/1261-21.
Aim There are more and more herbal preparations that are used for the purpose of treatment and improvement of the clinical manifestation of vaginitis not only by patients themselves, but also by healthcare professionals. Plant species, St. John's wort, chamomile, calendula, yarrow, shepherd's purse and tea tree oil are all well known for their anti-inflammatory, antimicrobial and wound healing activity. This paper presents the results of a clinical study in which three herbal formulations/vagitories, based on extracts of St. John's wort, chamomile, calendula, yarrow, shepherd's purse and tea tree oil, were investigated for their effectiveness on vaginitis. Methods This was a randomized controlled clinical study that included 210 women with diagnosed vaginitis. Patients were divided into two basic groups, women in reproductive period and postmenopausal period. Three subgroups including 30 patients each received one of the three vagitorie formulations for 5 days, after which the effects on subjective and objective symptoms were monitored. Results Three types of vagitories based on plant extracts had a positive effect in the treatment of vaginitis. Vagitories based on tea tree oil showed better efficiency compared to vagitories with St. John's wort and vagitories based on extracts of five plants. Women in postmenopausal group reported better tolerability of St. John's wort-based and five herbs-based vagitories compared to tea tree oil based vagitories. Conclusion Investigated vagitories showed a positive effect on both objective and subjective symptoms of vagitnis. No serious side effects were reported.
目的 越来越多的草药制剂不仅被患者自身，也被医疗保健专业人员用于治疗和改善阴道炎的临床表现。圣约翰草、甘菊、金盏花、蓍草、马齿苋和茶树油等植物物种因其具有抗炎、抗菌和促进伤口愈合的作用而广为人知。本文介绍了一项临床研究的结果，该研究调查了三种基于圣约翰草、甘菊、金盏花、蓍草、马齿苋和茶树油提取物的草药制剂/阴道栓剂在治疗阴道炎方面的有效性。
方法 这是一项随机对照临床研究，纳入了 210 名确诊患有阴道炎的女性患者。患者分为两个基本组，即育龄期和绝经后妇女。每组包括 30 名患者，分别使用三种阴道栓剂中的一种进行为期 5 天的治疗，然后监测对主观和客观症状的影响。
结果 基于植物提取物的三种阴道栓剂对阴道炎的治疗均有积极效果。与圣约翰草和五种植物提取物阴道栓剂相比，茶树油阴道栓剂显示出更好的疗效。绝经后妇女报告称，与茶树油阴道栓剂相比，圣约翰草和五种植物提取物阴道栓剂的耐受性更好。
结论 研究中的阴道栓剂对阴道炎的客观和主观症状均有积极效果。未报告严重的副作用。
