Turturro A, Hart R W
National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079.
Med Oncol Tumor Pharmacother. 1987;4(3-4):125-32. doi: 10.1007/BF02934508.
A better understanding of chemical-induced cancer has led to appreciation of similarities to problems addressed by risk management of radiation-induced toxicity. Techniques developed for cancer risk assessment of toxic substances can be generalized to toxic agents. A recent problem-solving approach for risk management of toxic substances developed for the U.S. Department of Health and Human Services, and the role of risk assessment and how uncertainty should be treated within the context of this approach, is discussed. Finally, two different methods, research into the assumptions underlying risk assessment and the modification of risk assessment/risk management documents, are used to illustrate how the technique can be applied.
对化学诱导癌症的更深入理解，使得人们认识到它与辐射诱导毒性风险管理所解决问题的相似之处。为有毒物质癌症风险评估所开发的技术可以推广到有毒剂。本文讨论了一种最近为美国卫生与公众服务部开发的有毒物质风险管理的解决问题方法，以及风险评估的作用，以及在这种方法的背景下应如何处理不确定性。最后，使用两种不同的方法，即对风险评估背后假设的研究和对风险评估/风险管理文件的修改，来说明该技术如何应用。
