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血液透析治疗的新进展。

Recent advances in treatment of haemodialysis.

机构信息

Department of Cardiovascular Sciences, 4488University of Leicester, Leicester LE1 7RH, UK.

Department of Renal Medicine, 4490University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.

出版信息

J R Soc Med. 2021 Jan;114(1):30-37. doi: 10.1177/0141076820972669. Epub 2020 Dec 3.

DOI:10.1177/0141076820972669
PMID:33269971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8173362/
Abstract

Haemodialysis remains the most widely used treatment for patients with end-stage renal disease. Despite the progress that has occurred in the treatment of end-stage renal disease over the last six decades, there has been a failure to translate this into the desired clinical benefits, with morbidity and mortality rates among patients on haemodialysis remaining unacceptably high. Recently, however, there have been expectations that the significant advances that took place over the last few years may result in improved outcomes. New medications for the treatment of anaemia and secondary hyperparathyroidism, as well as novel trends in the areas of iron therapy, diabetes management and physical exercise are among the most important advances which, taken together, are changing the standards of care for patients on haemodialysis. The latest advances, of relevance not only to specialists in Renal Medicine but also to general practitioners caring for these patients, are reviewed in this collaborative paper.

摘要

血液透析仍然是治疗终末期肾病患者最广泛使用的方法。尽管在过去六十年中,终末期肾病的治疗已经取得了进展,但并没有将其转化为理想的临床益处,血液透析患者的发病率和死亡率仍然高得令人无法接受。然而,最近人们开始期望,过去几年取得的重大进展可能会带来更好的结果。治疗贫血和继发性甲状旁腺功能亢进症的新药物,以及铁治疗、糖尿病管理和体育锻炼等领域的新趋势,是最重要的进展之一,这些进展共同改变了血液透析患者的护理标准。本文对这些最新进展进行了综述,这些进展不仅与肾脏科专家有关,也与照顾这些患者的全科医生有关。

相似文献

1
Recent advances in treatment of haemodialysis.血液透析治疗的新进展。
J R Soc Med. 2021 Jan;114(1):30-37. doi: 10.1177/0141076820972669. Epub 2020 Dec 3.
2
Intravenous iron and anaemia in haemodialysis patients.血液透析患者的静脉铁剂与贫血
Nephron. 1998 Dec;80(4):485. doi: 10.1159/000045230.
3
[The effect of hemodialysis and continuous ambulatory peritoneal dialysis on renal anemia].[血液透析和持续性非卧床腹膜透析对肾性贫血的影响]
Srp Arh Celok Lek. 1997 May-Jun;125(5-6):163-7.
4
Intravenous calcitriol improves anaemia and reduces the need for erythropoietin in haemodialysis patients.静脉注射骨化三醇可改善血液透析患者的贫血状况并减少促红细胞生成素的使用需求。
Nephron. 1998;78(1):23-7. doi: 10.1159/000044877.
5
Oral or parenteral iron therapy in haemodialysis patients?血液透析患者采用口服还是胃肠外铁剂治疗?
Proc Eur Dial Transplant Assoc. 1977;14:184-91.
6
Optimal treatment of renal anaemia (OPTA): improving the efficacy and efficiency of renal anaemia therapy in haemodialysis patients receiving intravenous epoetin.肾性贫血的优化治疗(OPTA):提高接受静脉注射促红细胞生成素的血液透析患者肾性贫血治疗的疗效和效率。
Nephrol Dial Transplant. 2005 May;20 Suppl 3:iii25-32. doi: 10.1093/ndt/gfh1071.
7
Reasons for differences in dose requirements of recombinant human erythropoietin in haemodialysis patients.血液透析患者重组人促红细胞生成素剂量需求差异的原因
Contrib Nephrol. 1990;82:55-64. doi: 10.1159/000418718.
8
Evolution of anemia of chronic renal failure after the treatment of hyperparathyroidism.甲状旁腺功能亢进治疗后慢性肾衰竭贫血的演变
Nephron. 1996;74(2):444-5. doi: 10.1159/000189359.
9
Frequency of administration of recombinant human erythropoietin for anaemia of end-stage renal disease in dialysis patients.终末期肾病透析患者中重组人促红细胞生成素治疗贫血的给药频率
Cochrane Database Syst Rev. 2002(4):CD003895. doi: 10.1002/14651858.CD003895.
10
Hyperparathyroidism and anemia in chronic renal failure.慢性肾衰竭中的甲状旁腺功能亢进与贫血
Eur J Pediatr. 1982 Dec;139(4):296-8. doi: 10.1007/BF00442185.

引用本文的文献

1
The association of serum albumin with 28 day mortality in critically ill patients undergoing dialysis: a secondary analysis based on the eICU collaborative research database.血清白蛋白与接受透析治疗的危重症患者 28 天死亡率的相关性:基于 eICU 协作研究数据库的二次分析。
Eur J Med Res. 2024 Nov 5;29(1):530. doi: 10.1186/s40001-024-02127-5.

本文引用的文献

1
Renal Association Clinical Practice Guideline on Haemodialysis.英国肾脏病学会血液透析临床实践指南
BMC Nephrol. 2019 Oct 17;20(1):379. doi: 10.1186/s12882-019-1527-3.
2
Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis.罗沙司他治疗长期透析患者的贫血。
N Engl J Med. 2019 Sep 12;381(11):1011-1022. doi: 10.1056/NEJMoa1901713. Epub 2019 Jul 24.
3
Cardiovascular adaptations associated with exercise in patients on hemodialysis.血液透析患者运动相关的心血管适应性变化
Semin Dial. 2019 Jul;32(4):361-367. doi: 10.1111/sdi.12789. Epub 2019 Mar 24.
4
KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).KDIGO 2017慢性肾脏病-矿物质和骨异常(CKD-MBD)诊断、评估、预防及治疗临床实践指南更新
Kidney Int Suppl (2011). 2017 Jul;7(1):1-59. doi: 10.1016/j.kisu.2017.04.001. Epub 2017 Jun 21.
5
Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.维持性血液透析患者的静脉铁剂治疗。
N Engl J Med. 2019 Jan 31;380(5):447-458. doi: 10.1056/NEJMoa1810742. Epub 2018 Oct 26.
6
Management of adults with diabetes on the haemodialysis unit: summary of guidance from the Joint British Diabetes Societies and the Renal Association.血液透析单位成人糖尿病患者的管理:英国糖尿病学会联合会和肾脏协会指南摘要。
Diabet Med. 2018 Aug;35(8):1018-1026. doi: 10.1111/dme.13676.
7
Chapter 7 Haemoglobin, Ferritin and Erythropoietin in UK Adult Dialysis Patients in 2016: National and.第7章 2016年英国成年透析患者的血红蛋白、铁蛋白和促红细胞生成素:全国性及……
Nephron. 2018;139 Suppl 1:165-190. doi: 10.1159/000490965. Epub 2018 Jul 10.
8
Long-term treatment with biosimilar epoetin-α (HX575) in hemodialysis patients with renal anemia: real-world effectiveness and safety in the MONITOR-CKD5 study
.生物类似物促红细胞生成素-α(HX575)对肾性贫血血液透析患者的长期治疗:MONITOR-CKD5研究中的真实疗效和安全性
Clin Nephrol. 2018 Jan;89 (2018)(1):1-9. doi: 10.5414/CN109245.
9
Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects With and Without Renal Impairment.在有和无肾功能损害的受试者中单次给予司美格鲁肽(一种人胰高血糖素样肽-1 类似物)的药代动力学和耐受性。
Clin Pharmacokinet. 2017 Nov;56(11):1381-1390. doi: 10.1007/s40262-017-0528-2.
10
Design and methods of CYCLE-HD: improving cardiovascular health in patients with end stage renal disease using a structured programme of exercise: a randomised control trial.CYCLE-HD的设计与方法:采用结构化运动方案改善终末期肾病患者的心血管健康:一项随机对照试验
BMC Nephrol. 2016 Jul 8;17(1):69. doi: 10.1186/s12882-016-0294-7.