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[免疫荧光法在乳糜泻中麦醇溶蛋白抗体测定中的应用]

[Immunofluorescence in the determination of gliadin antibodies in celiac disease].

作者信息

Castro M, Castellucci G, Papadatou B, Bragetti P, Ferretti F, Maggi S, Lucidi V, Poletti C

机构信息

Ospedale Bambino Gesù, Servizio di Gastroenterologia e Nutrizione, Roma, Italia.

出版信息

Pediatr Med Chir. 1987 Sep-Oct;9(5):585-7.

PMID:3327055
Abstract

IgG gliadin antibodies (AGA-IgG) were detected by immunofluorescence in 78 celiac children diagnosed by jejunal biopsy. AGA-IgG were also detected in patients affected by other gastrointestinal disease, in patients with diabetes, in health children and in children with normal mucosa. AGA-IgG were found in 81% of celiac patients, while they were not detected in patients affected by other intestinal or extraintestinal diseases, neither in healthy controls. It is conclude that determination of AGA-IgG is a very specific and sensitive enough screening test before small intestinal biopsy.

摘要

通过免疫荧光法在78名经空肠活检确诊的乳糜泻患儿中检测到IgG麦醇溶蛋白抗体(AGA-IgG)。在患有其他胃肠道疾病的患者、糖尿病患者、健康儿童以及黏膜正常的儿童中也检测到了AGA-IgG。81%的乳糜泻患者检测到AGA-IgG,而在患有其他肠道或肠道外疾病的患者以及健康对照中均未检测到。结论是,在进行小肠活检之前,检测AGA-IgG是一种非常特异且足够敏感的筛查试验。

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