Department of Geriatric Medicine, The University of Tokyo Graduate School of Medicine Faculty of Medicine, Tokyo, Japan.
Research Institute of Aging Science, Abe Clinic, Tokyo, Japan.
PLoS One. 2020 Dec 3;15(12):e0243242. doi: 10.1371/journal.pone.0243242. eCollection 2020.
Metabolic syndrome (MetS) is an important predictor of mortality in older adulthood, but it is not reliably related to measures of body composition such as body mass index in older adults, as opposed to those in earlier life stages. Previous research suggests that skeletal muscle mass is related to cardiovascular risk in older adulthood, but it is difficult to measure muscle mass accurately and independently of body fat. This study aimed to examine the relationship between body composition and cardiovascular risk factors among women in older adulthood. A cross-sectional observational clinical study was conducted at a single medical clinic in Tokyo, Japan. Participants included 90 healthy Japanese women aged 65 years and older. MetS risk factors were assessed. Appendicular skeletal muscle mass (ASM) was assessed using dual-emission X-ray absorptiometry. Visceral fat area (VFA) was measured using computed tomography. VFA positively correlated with ASM and MetS, whereas ASM and MetS did not correlate with each other. Using VFA and ASM data in a MetS multiple linear regression model, the association between VFA and MetS remained positive, whereas a significant negative relationship emerged between ASM and MetS. Lower muscle mass was independently associated with higher cardiovascular risk after controlling for VFA. Clinical interventions to reduce muscle loss in older adulthood may be beneficial for reducing the risk of MetS and improving cardiovascular health.
代谢综合征（MetS）是老年期死亡率的重要预测指标，但与身体成分的衡量标准（如体重指数）不同，它与老年人的身体成分没有可靠的关系，而与生命早期阶段的身体成分有关。先前的研究表明，骨骼肌质量与老年期的心血管风险有关，但很难准确地、独立于体脂肪来测量肌肉质量。本研究旨在探讨老年期女性身体成分与心血管危险因素之间的关系。在日本东京的一家医疗诊所进行了一项横断面观察性临床研究。参与者包括 90 名年龄在 65 岁及以上的健康日本女性。评估了 MetS 的危险因素。使用双能 X 射线吸收法评估四肢骨骼肌质量（ASM）。使用计算机断层扫描测量内脏脂肪面积（VFA）。VFA 与 ASM 和 MetS 呈正相关，而 ASM 和 MetS 之间没有相关性。在 MetS 多元线性回归模型中使用 VFA 和 ASM 数据，VFA 与 MetS 之间的关联仍然呈阳性，而 ASM 与 MetS 之间呈显著负相关。在控制 VFA 后，较低的肌肉质量与较高的心血管风险独立相关。在老年期减少肌肉流失的临床干预可能有助于降低 MetS 的风险，改善心血管健康。
