Kim Su Jin
Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Int Neurourol J. 2020 Nov;24(Suppl 2):67-71. doi: 10.5213/inj.2040426.213. Epub 2020 Nov 23.
Apoptosis has been found in bladder affected by various types of voiding dysfunction. In animal studies, higher levels of apoptosis were observed in conditions of both detrusor overactivity and underactivity than in normal bladders. However, it has been difficult to establish the exact underlying mechanism of apoptosis in these conditions and to find new therapeutic targets because the causes of voiding dysfunction are diverse and the coexistence of various types of voiding problems is common. Furthermore, the lack of studies of the human detrusor contributes to our incomplete understanding of these issues. Therefore, this revies discuss the role of apoptosis in detrusor contractility based on previous studies.
在受各种类型排尿功能障碍影响的膀胱中已发现细胞凋亡。在动物研究中，与正常膀胱相比，在逼尿肌过度活动和活动不足的情况下均观察到更高水平的细胞凋亡。然而，由于排尿功能障碍的原因多种多样且各种类型的排尿问题共存很常见，因此很难确定这些情况下细胞凋亡的确切潜在机制并找到新的治疗靶点。此外，缺乏对人类逼尿肌的研究也导致我们对这些问题的理解不完整。因此，本综述基于先前的研究讨论细胞凋亡在逼尿肌收缩性中的作用。
