Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
J Microbiol Methods. 2021 Jan;180:106109. doi: 10.1016/j.mimet.2020.106109. Epub 2020 Nov 30.
MALDI-TOF MS is an effective potential tool to distinguish between MSSA and MRSA. By combining the ClinProTools3.0 software and manual grouping intervention, we proposed a model optimization method for the first time. The cross validation of the model increased from 95.82% to 96.68%, and the accuracy of the model increased from 88.89% to 91.98%. Finally, we reported nine characteristic peaks of rapid detection of MRSA.
基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）是一种有效的潜在工具，可用于区分 MSSA 和 MRSA。通过结合 ClinProTools3.0 软件和手动分组干预，我们首次提出了一种模型优化方法。模型的交叉验证率从 95.82%提高到 96.68%，模型的准确性从 88.89%提高到 91.98%。最后，我们报告了快速检测 MRSA 的九个特征峰。
