Katsenovich R A, Trigulova R Kh, Kostko S Z
Ter Arkh. 1987;59(11):35-8.
Nifedipine influence on a clinical course of angina pectoris, some indices of hemodynamics, glucose and insulin was studied in 39 male patients suffering from coronary heart disease (CHD) with different glucose tolerance. In CHD patients with normal glucose tolerance (NGT) nifedipine therapy did not cause any considerable changes in the blood levels of glucose and insulin whereas in patients with lowered glucose tolerance (LGT) a hypoglycemic effect of the drug and an increase in the level of insulin were noted during therapy. An increase in physical exercise tolerance, a decrease in the frequency of anginal attacks, and a decrease in the number of nitroglycerin tablets administered by CHD patients with LGT per week were significant. The study showed that nifedipine was indicated for CHD patients with LGT.
对39例患有不同糖耐量的冠心病男性患者，研究了硝苯地平对心绞痛临床病程、一些血流动力学指标、血糖和胰岛素的影响。在糖耐量正常（NGT）的冠心病患者中，硝苯地平治疗未引起血糖和胰岛素血水平的任何显著变化，而在糖耐量降低（LGT）的患者中，治疗期间注意到该药物有降血糖作用且胰岛素水平升高。LGT的冠心病患者的体力运动耐量增加、心绞痛发作频率降低以及每周服用硝酸甘油片的数量减少均有显著意义。该研究表明，硝苯地平适用于LGT的冠心病患者。
