Voronkov L G, Sokolov N F
Farmakol Toksikol. 1988 Sep-Oct;51(5):38-41.
Some clinical, hemodynamic and biochemical parameters were studied in 25 patients with ischemic heart disease of II-III functional classes depending on the presence of the antianginal effect during paired loading pharmacodynamic tests with corinfar. The antianginal effect of corinfar was found to be associated with a marked growth of "double product" and the presence of a clinical symptom of adaptation. In patients with the lack of corinfar antianginal effect there were noted the adaptation symptom absence and a higher blood catecholamine level. A decrease of the postloading did not correlate with the drug antianginal effect. The data could indicate that in the mechanism of corinfar antianginal effect the determining factor is its direct influence on the coronary circulation.
对25例II - III级功能类别的缺血性心脏病患者，根据在使用可立泛进行配对负荷药效学试验期间是否存在抗心绞痛作用，研究了一些临床、血流动力学和生化参数。发现可立泛的抗心绞痛作用与“双乘积”的显著增加以及适应的临床症状的存在有关。在缺乏可立泛抗心绞痛作用的患者中，未观察到适应症状且血儿茶酚胺水平较高。负荷后降低与药物抗心绞痛作用无关。这些数据可能表明，在可立泛抗心绞痛作用机制中，决定因素是其对冠脉循环的直接影响。
