Kostko S Z, Arifdzhanova U A, Vakhidova M A, Trigulova R Kh, Kasymkhodzhaev A Sh
Ter Arkh. 1986;58(5):77-81.
A study of the antianginal efficacy of corinfar therapy by courses at daily doses of 30 and 60 mg (14 days) was carried out in 20 patients (males) with typical angina pectoris. Individual variability of response to the studied drug doses was noted. A high increment of tolerance to physical exercise on the bicycle ergometer was noted in the 1st group of patients using even small doses (30mg), in the 2nd group the antianginal effect was observed after increasing the dose up to 60 mg and in the 3rd group no effect was observed with any of the doses. Corinfar therapy did not influence the heart rate (HR), systolic and diastolic arterial pressure (SAP, DAP) and the double derivative (SAP X HR) at rest. A significant decrease in the above parameters as compared to the initial ones was noted in physical exercise at the level of the control test. At the maximum level of exercise the parameters corresponded to those of the initial test.
对20名患有典型心绞痛的男性患者进行了一项研究，以每日剂量30毫克和60毫克（持续14天）的疗程来观察可立泛（Corinfar）治疗的抗心绞痛疗效。研究发现，患者对所研究药物剂量的反应存在个体差异。在第一组使用小剂量（30毫克）的患者中，观察到在自行车测力计上对体育锻炼的耐受性有显著提高；在第二组中，将剂量增加到60毫克后观察到了抗心绞痛效果；而在第三组中，任何剂量都未观察到效果。可立泛治疗对静息时的心率（HR）、收缩压和舒张压（SAP、DAP）以及双乘积（SAP×HR）没有影响。与初始参数相比，在对照测试水平的体育锻炼中，上述参数显著降低。在最大运动水平时，这些参数与初始测试时的参数相当。
