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弥漫特发性骨肥厚症患者的异位骨化：组织学发现的启示。

Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings.

机构信息

Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona.

出版信息

Eur J Histochem. 2020 Dec 3;64(4):3176. doi: 10.4081/ejh.2020.3176.

DOI:10.4081/ejh.2020.3176
PMID:33272008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7731577/
Abstract

A high incidence of heterotopic ossification (HO) has been reported in patients with diffuse idiopathic skeletal hyperostosis (DISH), a metabolic disease characterized by calcifications of entheses at spine and peripheral sites. We performed histological and immunohistochemical analyses in five different HO sites in a patient with DISH to study a possible mutual interaction of bone morphogenetic protein 2 (BMP-2), transforming growth factor beta (TGF-β), and decorin, crucial for bone mass increasing, matrix calcification, and endochondral bone formation. We speculated that the surgical trauma triggered HO, inducing TGF-β release at the lesion site. TGF-β recruits osteoblast precursor cells and determines the overexpression of BMP-2 in the surrounding skeletal muscle, inducing a further osteogenic differentiation, contributing to HO onset.

摘要

弥漫性特发性骨肥厚（DISH）是一种代谢性疾病，其特征为脊柱和外周附着点的钙化，有报道称该病患者的异位骨化（HO）发病率较高。我们对一名 DISH 患者的五个不同 HO 部位进行了组织学和免疫组织化学分析，以研究对骨量增加、基质钙化和软骨内骨形成至关重要的骨形态发生蛋白 2（BMP-2）、转化生长因子-β（TGF-β）和核心蛋白聚糖（decorin）之间可能的相互作用。我们推测手术创伤引发了 HO，导致病变部位 TGF-β 的释放。TGF-β 募集成骨前体细胞，并确定周围骨骼肌中 BMP-2 的过度表达，诱导进一步的成骨分化，有助于 HO 的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/b00290ebf2cb/ejh-64-4-3176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/59d1d993e1b4/ejh-64-4-3176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/73643362a122/ejh-64-4-3176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/b00290ebf2cb/ejh-64-4-3176-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/59d1d993e1b4/ejh-64-4-3176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/73643362a122/ejh-64-4-3176-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79be/7731577/b00290ebf2cb/ejh-64-4-3176-g003.jpg

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