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土耳其一家三级转诊中心角膜供体的流行病学特征:一项眼库研究。

Epidemiological Characteristics of Corneal Donors at a Tertiary Referral Center in Turkey: An Eye Bank Study.

机构信息

From the University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.

出版信息

Exp Clin Transplant. 2021 Apr;19(4):367-373. doi: 10.6002/ect.2020.0310. Epub 2020 Nov 27.

Abstract

OBJECTIVES

The aim of this study was to evaluate the demographic features of corneal donors and available data of corneas in our eye bank during a 14-year period.

MATERIALS AND METHODS

The demographic features of the corneal donors, the causes of death, the death-to-excision interval, serology results, the mean endothelial cell density, and the reasons for discarding the corneas were retrospectively evaluated.

RESULTS

During the study period, 6524 corneas were retrieved from 3326 donors (76.1% male, 23.9% female). Mean donor age was 43.7 ± 16.0 years (range, 4-75 years; median 45.0 years). The most common cause of death was cardiovascular disease (n = 1467; 44.1%). The most common reason for discarding corneas was positive serology (n = 509; 78.6%). The mean endothelial cell density was 3030.1 ± 484.3 cells/mm². There was a weak negative statistically significant correlation between age and endothelial cell density (Pearson correlation coefficient r = -0.187, P < .001). Multiorgan donations made up 1.5% of the whole group (n = 50).

CONCLUSIONS

We believe that preoperative detailed evaluations of graft quality in addition to review of donor-related medical records and data from previous surgeries, after collecting them in a single system, will have a positive effect on postoperative corneal survival.

摘要

目的

本研究旨在评估 14 年间眼库中角膜供体的人口统计学特征和角膜相关数据。

材料与方法

回顾性评估角膜供体的人口统计学特征、死亡原因、死亡至切除间隔时间、血清学结果、平均内皮细胞密度以及角膜废弃的原因。

结果

研究期间,从 3326 名供体中获取了 6524 枚角膜(76.1%为男性,23.9%为女性)。供体平均年龄为 43.7 ± 16.0 岁(范围 4-75 岁;中位数 45.0 岁)。最常见的死亡原因为心血管疾病(n = 1467;44.1%)。最常见的角膜废弃原因是血清学阳性(n = 509;78.6%)。平均内皮细胞密度为 3030.1 ± 484.3 个细胞/mm²。年龄与内皮细胞密度呈弱负相关(皮尔逊相关系数 r = -0.187,P <.001)。多器官捐献占总捐献数的 1.5%(n = 50)。

结论

我们认为,除了审查供体相关病历和以前手术的数据外,术前还应详细评估移植物质量,将这些信息收集到一个系统中,这将对术后角膜存活率产生积极影响。

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