Heart & Brain Laboratory, Western University, London, Ontario, Canada; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics, and Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Robarts Research Institute, London, Ontario, Canada.
University of Erlangen-Nuremberg, Erlangen, Germany; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.
J Am Coll Cardiol. 2020 Dec 8;76(23):2768-2785. doi: 10.1016/j.jacc.2020.10.009.
Over 1.5 million deaths worldwide are caused by neurocardiogenic syndromes. Furthermore, the consequences of deleterious brain-heart interactions are not limited to fatal complications. Cardiac arrhythmias, heart failure, and nonfatal coronary syndromes are also common. The brain-heart axis is implicated in post-stroke cardiovascular complications known as the stroke-heart syndrome, sudden cardiac death, and Takotsubo syndrome, among other neurocardiogenic syndromes. Multiple pathophysiological mechanisms with the potential to be targeted with novel therapies have been identified in the last decade. In the present state-of-the-art review, we describe recent advances in the understanding of anatomical and functional aspects of the brain-heart axis, cardiovascular complications after stroke, and a comprehensive pathophysiological model of stroke-induced cardiac injury.
全世界有超过 150 万人的死亡是由神经心源性综合征引起的。此外，有害的脑心相互作用的后果不仅限于致命的并发症。心律失常、心力衰竭和非致命性冠状动脉综合征也很常见。脑心轴与称为卒中-心综合征、心源性猝死和心尖球囊综合征等神经心源性综合征的中风后心血管并发症有关。在过去的十年中，已经确定了多个具有潜在靶向新型治疗方法的病理生理机制。在本综述的最新进展中，我们描述了对脑心轴的解剖和功能方面、中风后的心血管并发症以及中风引起的心脏损伤的综合病理生理学模型的理解的最新进展。
