Departments of Neurology and Neurosurgery, University of Colorado, Aurora, CO, United States.
Departments of Neurology and Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, United States.
Handb Clin Neurol. 2021;176:229-248. doi: 10.1016/B978-0-444-64034-5.00019-5.
Hemorrhagic stroke comprises about 20% of all strokes, with intracerebral hemorrhage (ICH) being the most common type. Frequency of ICH is increased where hypertension is untreated. ICH in particularly has a disproportionately high risk of early mortality and long-term disability. Until recently, there has been a paucity of randomized controlled trials (RCTs) to provide evidence for the efficacy of various commonly considered interventions in ICH, including acute blood pressure management, coagulopathy reversal, and surgical hematoma evacuation. Evidence-based guidelines do exist for ICH and these form the basis for a framework of care. Current approaches emphasize control of extremely high blood pressure in the acute phase, rapid reversal of vitamin K antagonists, and surgical evacuation of cerebellar hemorrhage. Lingering questions, many of which are the topic of ongoing clinical research, include optimizing individual blood pressure targets, reversal strategies for newer anticoagulant medications, and the role of minimally invasive surgery. Risk stratification models exist, which derive from findings on clinical exam and neuroimaging, but care should be taken to avoid a self-fulfilling prophecy of poor outcome from limiting treatment due to a presumed poor prognosis. Cerebral venous thrombosis is an additional subtype of hemorrhagic stroke that has a unique set of causes, natural history, and treatment and is discussed as well.
出血性脑卒中约占所有脑卒中的 20%,其中脑出血(ICH)是最常见的类型。未治疗的高血压会增加 ICH 的发病率。ICH 尤其具有极高的早期死亡率和长期残疾风险。直到最近,仍缺乏随机对照试验(RCT)来为各种常见干预措施在 ICH 中的疗效提供证据,这些干预措施包括急性血压管理、凝血功能障碍逆转和手术血肿清除。ICH 确实存在循证指南,这些指南构成了护理框架的基础。目前的方法强调在急性期控制极高的血压、快速逆转维生素 K 拮抗剂以及小脑出血的手术清除。仍存在悬而未决的问题,其中许多是正在进行的临床研究的主题,包括优化个体血压目标、针对新型抗凝药物的逆转策略以及微创手术的作用。存在风险分层模型,这些模型源自临床检查和神经影像学的发现,但应注意避免由于假定的预后不佳而限制治疗导致不良结果的自我实现预言。脑静脉血栓形成是一种额外的出血性脑卒中亚型,具有独特的病因、自然史和治疗方法,也将进行讨论。