不明病因的慢性肾脏病：印度的病例定义——一种观点
Chronic Kidney Disease of Unknown Etiology: Case Definition for India - A Perspective.
作者信息
Anupama Y J, Sankarasubbaiyan Suresh, Taduri Gangadhar
机构信息
Department of Nephrology, Nanjappa Hospital, Shivamogga, Karnataka, India.
Department of Nephrology, DaVita Kidney Care, Chennai, Tamil Nadu, India.
出版信息
Indian J Nephrol. 2020 Jul-Aug;30(4):236-240. doi: 10.4103/ijn.IJN_327_18. Epub 2019 Sep 6.
Abstract
Chronic kidney disease of unknown etiology (CKDu) is a form of chronic kidney disease (CKD) that is prevalent in certain rural populations around the world. It is distinct by its clinicopathologic characteristics and has multifactorial etiology, being mostly linked to several environmental toxins. Although the presentation is similar in various regions across the globe, it also differs in subtle ways from region to region. In India too, there have been reports of the disease in several pockets. There is a need for a comprehensive definition to identify the cases accurately to ease clinical diagnosis and facilitate screening of populations in affected areas. This article presents the diagnostic criteria for CKDu proposed in a consensus meeting at Chennai, India, in May 2017.
摘要
病因不明的慢性肾脏病（CKDu）是一种慢性肾脏病（CKD），在世界各地的某些农村人口中普遍存在。它因其临床病理特征而独特，病因多因素，主要与几种环境毒素有关。尽管全球不同地区的表现相似，但地区之间也存在细微差异。在印度，也有几个地区报告了这种疾病。需要一个全面的定义来准确识别病例，以简化临床诊断并促进对受影响地区人群的筛查。本文介绍了2017年5月在印度金奈举行的一次共识会议上提出的CKDu诊断标准。
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2
Deleterious role of trace elements - Silica and lead in the development of chronic kidney disease.微量元素——硅和铅在慢性肾脏病发展中的有害作用。
Chemosphere. 2017 Jun;177:239-249. doi: 10.1016/j.chemosphere.2017.02.155. Epub 2017 Mar 1.
3
Chronic kidney disease of unknown etiology in Sri Lanka.斯里兰卡病因不明的慢性肾脏病
Int J Occup Environ Health. 2016 Jul;22(3):259-264. doi: 10.1080/10773525.2016.1203097. Epub 2016 Jul 11.
4
Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis.全球慢性肾脏病患病率——一项系统评价与荟萃分析
PLoS One. 2016 Jul 6;11(7):e0158765. doi: 10.1371/journal.pone.0158765. eCollection 2016.
5
Uddanam Nephropathy/Regional Nephropathy in India: Preliminary Findings and a Plea for Further Research.印度乌德讷姆肾病/地区性肾病：初步研究结果及进一步研究的呼吁
Am J Kidney Dis. 2016 Sep;68(3):344-8. doi: 10.1053/j.ajkd.2016.04.012. Epub 2016 May 19.
6
Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy.气候变化与农村社区热应激引发的慢性肾脏病流行：热应激肾病案例
Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1472-1483. doi: 10.2215/CJN.13841215. Epub 2016 May 5.
7
Chronic kidney disease hotspots in developing countries in South Asia.南亚发展中国家的慢性肾脏病高发地区
Clin Kidney J. 2016 Feb;9(1):135-41. doi: 10.1093/ckj/sfv109. Epub 2015 Nov 17.
8
Global dimensions of chronic kidney disease of unknown etiology (CKDu): a modern era environmental and/or occupational nephropathy?不明病因慢性肾脏病（CKDu）的全球层面：一种现代环境和/或职业性肾病？
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9
Chronic kidney disease of unknown etiology in agricultural communities.农业社区中病因不明的慢性肾脏病
MEDICC Rev. 2014 Apr;16(2):9-15. doi: 10.37757/MR2014.V16.N2.3.
10
CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy.中美洲不明原因的慢性肾脏病：中美洲肾病的案例。
Am J Kidney Dis. 2014 Mar;63(3):506-20. doi: 10.1053/j.ajkd.2013.10.062. Epub 2014 Jan 10.
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