Department of Biochemistry, Environmental Biochemistry and Immunology Laboratory, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Dilshad Garden, Delhi, 110095, India.
Multidisciplinary Research Unit, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Dilshad Garden, Delhi, 110095, India.
Environ Health Prev Med. 2017 May 26;22(1):49. doi: 10.1186/s12199-017-0660-5.
Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study.
All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100). Blood OCP levels of all three study groups were analyzed by gas chromatography.
Increased level of OCPs, namely α-HCH, aldrin, and β-endosulfan, were observed in CKDu patients as compared to healthy control and CKD patients of known etiology. The levels of these pesticides significantly correlated negatively with the estimated glomerular filtration rate (eGFR) and positively with urinary albumin of CKD patients. Logistic regression analysis revealed association of γ-HCH, p, p'-DDE, and β-endosulfan with CKDu on adjustment of age, sex, BMI, and total lipid content.
Increased blood level of certain organochlorine pesticides is associated with the development of chronic kidney disease of unknown etiology.
有研究表明，农用化学品的使用与病因不明的慢性肾脏病（CKDu）的发生有关。本研究旨在探讨 CKDu 患者血液中有机氯农药（OCPs）水平与 CKDu 之间的关系。
将所有招募的研究对象（n=300）分为三组，即健康对照组（n=100）、病因不明的慢性肾脏病患者组（n=100）和已知病因的慢性肾脏病患者组（CKDk）（n=100）。采用气相色谱法分析三组研究对象的血液 OCP 水平。
与健康对照组和 CKD 患者相比，CKDu 患者血液中 OCPs 水平升高，包括α-HCH、艾氏剂和β-硫丹。这些农药的水平与估计肾小球滤过率（eGFR）呈显著负相关，与 CKD 患者的尿白蛋白呈显著正相关。Logistic 回归分析显示，在调整年龄、性别、BMI 和总脂质含量后，γ-HCH、p，p'-DDE 和β-硫丹与 CKDu 存在关联。
某些有机氯农药血液水平升高与病因不明的慢性肾脏病的发生有关。
