Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital, Republic of Korea.
Department of Statistics, University of Michigan, Michigan, USA.
Biomed Res Int. 2020 Nov 25;2020:2054376. doi: 10.1155/2020/2054376. eCollection 2020.
Owing to its worldwide spread, the coronavirus disease (COVID-19) epidemic was declared a pandemic by the World Health Organization on March 11, 2020. Angiotensin-converting enzyme 2 (ACE2) is the outer surface protein of the cell membrane that is abundantly distributed in the heart, lungs, and kidneys and plays an important role in molecular docking of the severe acute respiratory syndrome coronavirus 2. In this study, we aimed to analyze the difference in the survival rate according to ACE2 expressions in pan-cancer.
We downloaded clinical and genomic data from The Cancer Genome Atlas. We used Kaplan-Meier with a log-rank test, and the Cox proportional hazards regression to analyze prognostic significance.
In the Kaplan-Meier curve, clear cell renal cell carcinoma (ccRCC), uveal melanoma, and prostate adenocarcinoma showed statistical significance. In the Cox regression, thyroid carcinoma and glioblastoma multiforme and ccRCC showed significant results. Only ccRCC had statistical significance, and high ACE2 expression is related to good prognosis. It is known that the ACE inhibitor, a primary antihypertensive agent, increases ACE2 expression.
Based on these results, we believe that the ACE inhibitor will be important to increase the lifespan of ccRCC patients. This study is the first research to offer a recommendation on the use of anti-hypertensive drugs to ccRCC patients.
由于其在全球范围内的传播，世界卫生组织于 2020 年 3 月 11 日宣布冠状病毒病（COVID-19）疫情为大流行。血管紧张素转换酶 2（ACE2）是细胞膜的外表面蛋白，在心脏、肺和肾脏中大量分布，在严重急性呼吸系统综合征冠状病毒 2 的分子对接中发挥重要作用。在本研究中，我们旨在分析在泛癌中根据 ACE2 表达的生存率差异。
我们从癌症基因组图谱下载了临床和基因组数据。我们使用 Kaplan-Meier 与对数秩检验，以及 Cox 比例风险回归分析预后意义。
在 Kaplan-Meier 曲线中，透明细胞肾细胞癌（ccRCC）、葡萄膜黑色素瘤和前列腺腺癌显示出统计学意义。在 Cox 回归中，甲状腺癌和胶质母细胞瘤多形性和 ccRCC 显示出显著结果。只有 ccRCC 具有统计学意义，高 ACE2 表达与良好的预后相关。已知血管紧张素转换酶抑制剂是一种主要的降压药，可增加 ACE2 的表达。
基于这些结果，我们认为 ACE 抑制剂对于增加 ccRCC 患者的寿命将非常重要。本研究是第一项推荐使用抗高血压药物治疗 ccRCC 患者的研究。
