Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, UAE.
J Diabetes Res. 2020 Nov 13;2020:1942086. doi: 10.1155/2020/1942086. eCollection 2020.
Diabetes mellitus (DM) is a chronic metabolic disorder commonly characterized by high blood glucose levels, resulting from defects in insulin production or insulin resistance, or both. DM is a leading cause of mortality and morbidity worldwide, with diabetic cardiomyopathy as one of its main complications. It is well established that cardiovascular complications are common in both types of diabetes. Electrical and mechanical problems, resulting in cardiac contractile dysfunction, are considered as the major complications present in diabetic hearts. Inevitably, disturbances in the mechanism(s) of Ca signaling in diabetes have implications for cardiac myocyte contraction. Over the last decade, significant progress has been made in outlining the mechanisms responsible for the diminished cardiac contractile function in diabetes using different animal models of type I diabetes mellitus (TIDM) and type II diabetes mellitus (TIIDM). The aim of this review is to evaluate our current understanding of the disturbances of Ca transport and the role of main cardiac proteins involved in Ca homeostasis in the diabetic rat ventricular cardiomyocytes. Exploring the molecular mechanism(s) of altered Ca signaling in diabetes will provide an insight for the identification of novel therapeutic approaches to improve the heart function in diabetic patients.
糖尿病（DM）是一种常见的慢性代谢紊乱，其特征通常为高血糖水平，这是由于胰岛素产生或胰岛素抵抗或两者兼有缺陷所致。DM 是全球范围内导致死亡和发病的主要原因之一，糖尿病性心肌病是其主要并发症之一。众所周知，心血管并发症在两种类型的糖尿病中都很常见。电和机械问题导致心肌收缩功能障碍，被认为是糖尿病心脏的主要并发症。不可避免的是，糖尿病中 Ca 信号转导机制的紊乱对心肌细胞收缩有影响。在过去的十年中，使用不同的 1 型糖尿病（TIDM）和 2 型糖尿病（TIIDM）动物模型，在阐明导致糖尿病中心脏收缩功能减弱的机制方面取得了重大进展。本综述的目的是评估我们目前对 Ca 转运的紊乱以及参与 Ca 动态平衡的主要心脏蛋白的作用的理解，在糖尿病大鼠心室肌细胞中。探讨糖尿病中 Ca 信号转导改变的分子机制，将为确定改善糖尿病患者心脏功能的新治疗方法提供思路。
