糖尿病性心肌病。
Diabetic Cardiomyopathy.
机构信息
From the Division of Endocrinology/Metabolism, Department of Medicine, University of California, San Diego, La Jolla.
出版信息
Circ Res. 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665.
Abstract
Diabetic cardiomyopathy was initially described as a human pathophysiological condition in which heart failure occurred in the absence of coronary artery disease, hypertension, and valvular heart disease. Recent studies in diabetic animal models identify decreased cardiomyocyte function as an important mediating mechanism for heart failure. Decreased cardiomyocyte function is in part mediated by abnormal mitochondrial calcium handling and a decreased level of free matrix calcium levels which could be a good target for new therapeutic interventions.
摘要
糖尿病性心肌病最初被描述为一种人类病理生理学状态，其中心力衰竭发生在没有冠状动脉疾病、高血压和瓣膜性心脏病的情况下。最近在糖尿病动物模型中的研究确定了心肌细胞功能下降是心力衰竭的一个重要介导机制。心肌细胞功能下降部分是由异常的线粒体钙处理和基质钙水平降低介导的，这可能是新的治疗干预的一个很好的靶点。
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2
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3
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4
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Lancet. 2016 Mar 19;387(10024):1137-9. doi: 10.1016/S0140-6736(16)00149-5. Epub 2016 Jan 21.
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