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美国囤积瑞德西韦:世界应如何应对?

USA stockpiling of remdesivir: How should the world respond?

机构信息

Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Global Health Policy & Center for Global Development, London, UK.

出版信息

J Comp Eff Res. 2020 Dec;9(18):1243-1246. doi: 10.2217/cer-2020-0174. Epub 2020 Dec 4.

DOI:10.2217/cer-2020-0174
PMID:33274643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7717394/
Abstract

The race to find an effective treatment for coronavirus disease 2019 (COVID-19) is still on, with only two treatment options currently authorized for emergency use and/or recommended for patients hospitalized with severe respiratory symptoms: low-dose dexamethasone and remdesivir. The USA decision to stockpile the latter has resulted in widespread condemnation and in similar action being taken by some other countries. In this commentary we discuss whether stockpiling remdesivir is justified in light of the currently available evidence.

摘要

寻找针对 2019 冠状病毒病(COVID-19)的有效治疗方法的竞赛仍在继续,目前仅有两种治疗方案获得紧急使用授权和/或推荐给患有严重呼吸道症状的住院患者使用:低剂量地塞米松和瑞德西韦。美国决定储备瑞德西韦,这招致了广泛的谴责,一些其他国家也采取了类似行动。在本评论中,我们根据现有证据讨论了储备瑞德西韦是否合理。

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本文引用的文献

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Drug treatments for covid-19: living systematic review and network meta-analysis.Covid-19 的药物治疗:系统评价和网络荟萃分析。
BMJ. 2020 Jul 30;370:m2980. doi: 10.1136/bmj.m2980.
2
Dexamethasone in Hospitalized Patients with Covid-19.地塞米松在 COVID-19 住院患者中的应用。
N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17.
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US purchases world stocks of remdesivir: why the rest of the world should be glad to be at the back of the queue.
BMJ. 2020 Jul 13;370:m2797. doi: 10.1136/bmj.m2797.
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Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors.新型冠状病毒疾病 2019 患者的药物性肝损伤:瑞德西韦与 P-糖蛋白抑制剂的潜在相互作用。
Clin Infect Dis. 2021 Apr 8;72(7):1256-1258. doi: 10.1093/cid/ciaa883.
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Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19.瑞德西韦:对其发现与研发历程的综述,该历程促成了其用于治疗新冠病毒病的紧急使用授权
ACS Cent Sci. 2020 May 27;6(5):672-683. doi: 10.1021/acscentsci.0c00489. Epub 2020 May 4.
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Clinical evidence for repurposing chloroquine and hydroxychloroquine as antiviral agents: a systematic review.重新利用氯喹和羟氯喹作为抗病毒药物的临床证据:系统评价。
Clin Microbiol Infect. 2020 Aug;26(8):979-987. doi: 10.1016/j.cmi.2020.05.016. Epub 2020 May 26.
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Remdesivir for the Treatment of Covid-19 - Final Report.瑞德西韦治疗 COVID-19 的疗效 - 最终报告。
N Engl J Med. 2020 Nov 5;383(19):1813-1826. doi: 10.1056/NEJMoa2007764. Epub 2020 Oct 8.
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Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.瑞德西韦治疗成人重症 COVID-19 的随机、双盲、安慰剂对照、多中心临床试验。
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Cochrane Database Syst Rev. 2020 Apr 8;4(4):CD013574. doi: 10.1002/14651858.CD013574.
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