Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; and Istituto di Ematologia "Seràgnoli", Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale. Università degli Studi, Bologna, Italy.
Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):295-305. doi: 10.1182/hematology.2020000157.
Marginal zone lymphomas are indolent diseases. Overall survival rates are very good, but patients tend to relapse and may do so several times. The concept of treatment sequencing is therefore important and necessary to preserve adequate organ function and to avoid excessive toxicity, with the final goal of achieving long survival times. Systemic treatments and chemotherapy are considered to be an option in multiply relapsing disease, in cases that are in an advanced stage at presentation or relapse, and in cases where initial local treatments lack efficacy. Targeted agents and new drugs can provide chemotherapy-free alternatives in heavily pretreated patients.
边缘区淋巴瘤属于惰性疾病。总体生存率非常好，但患者往往会复发，且可能多次复发。因此，治疗顺序的概念非常重要且必要，这有助于保持适当的器官功能，避免过度毒性，最终目标是实现长期生存。对于多次复发的疾病、在初诊时处于晚期或复发时、以及初始局部治疗无效的病例，全身治疗和化疗被认为是一种选择。在经过大量预处理的患者中，靶向药物和新药可以提供无化疗的替代方案。
