NF-κB 与疾病。
NF-κB and Disease.
机构信息
Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.
出版信息
Int J Mol Sci. 2020 Dec 2;21(23):9181. doi: 10.3390/ijms21239181.
Abstract
The role of NF-κB in all diseases characterized by an inflammatory process, from cancer to autoimmune diseases, is known, but-precisely because it is involved in many diseases-this transcriptional factor continues to attract scientific research and the new knowledge that emerges is fundamental in highlighting the therapeutic potential that this factor can have in the various diseases in which it is involved [...].
摘要
NF-κB 在所有以炎症过程为特征的疾病中的作用，从癌症到自身免疫性疾病，都是已知的，但是——正因为它涉及许多疾病——这种转录因子仍然吸引着科学研究，并且新出现的知识对于突出该因子在其涉及的各种疾病中可能具有的治疗潜力是至关重要的[...]。
相似文献
1
NF-κB and Disease.NF-κB 与疾病。
Int J Mol Sci. 2020 Dec 2;21(23):9181. doi: 10.3390/ijms21239181.
2
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View.NF-κB 能否被视为肿瘤疾病的有效药物靶点？我们的观点。
Int J Mol Sci. 2020 Apr 27;21(9):3070. doi: 10.3390/ijms21093070.
3
NF-kappaB regulation in the immune system.免疫系统中的核因子-κB调控
Nat Rev Immunol. 2002 Oct;2(10):725-34. doi: 10.1038/nri910.
4
NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives.NF-κB-IKKβ 通路作为药物开发的靶点：现实、挑战与展望。
Curr Drug Targets. 2018;19(16):1933-1942. doi: 10.2174/1389450119666180219120534.
5
Long non-coding RNA: a versatile regulator of the nuclear factor-κB signalling circuit.长链非编码RNA：核因子κB信号通路的多功能调节因子
Immunology. 2017 Apr;150(4):379-388. doi: 10.1111/imm.12698. Epub 2017 Jan 19.
6
NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis.核因子-κB作为骨关节炎和类风湿关节炎的潜在治疗靶点。
Osteoarthritis Cartilage. 2006 Sep;14(9):839-48. doi: 10.1016/j.joca.2006.04.008. Epub 2006 May 26.
7
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology.多发性硬化症病理中的核因子 kappa B（NF-κB）。
Trends Mol Med. 2013 Oct;19(10):604-13. doi: 10.1016/j.molmed.2013.08.001. Epub 2013 Sep 2.
8
Signaling to NF-kappaB.向核因子κB发出信号。
Genes Dev. 2004 Sep 15;18(18):2195-224. doi: 10.1101/gad.1228704.
9
It takes two to tango: IκBs, the multifunctional partners of NF-κB.一个巴掌拍不响：IκBs，NF-κB 的多功能伙伴。
Immunol Rev. 2012 Mar;246(1):59-76. doi: 10.1111/j.1600-065X.2012.01102.x.
10
Post-translational control of NF-κB signaling by ubiquitination.泛素化对 NF-κB 信号转导的翻译后调控。
Arch Pharm Res. 2016 Aug;39(8):1075-84. doi: 10.1007/s12272-016-0772-2. Epub 2016 Jun 10.
引用本文的文献
1
A study on the mechanism of Bushen Kaiqiao Formula in modulating microglial activation to alleviate neuroinflammation in ADHD.补肾开窍方调控小胶质细胞活化减轻注意缺陷多动障碍神经炎症的机制研究
Biochem Biophys Rep. 2025 Aug 18;43:102211. doi: 10.1016/j.bbrep.2025.102211. eCollection 2025 Sep.
2
Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation.通过m6A-CXCL1/核因子κB调控揭示METTL3在幽门螺杆菌诱导的胃炎中的作用
Cell Death Dis. 2025 Aug 18;16(1):625. doi: 10.1038/s41419-025-07841-4.
3
Single-cell atlas of human skin implicates APOE pro-inflammatory signaling in diabetic foot ulcers.人类皮肤单细胞图谱揭示糖尿病足溃疡中APOE的促炎信号传导
Front Immunol. 2025 Jun 19;16:1591944. doi: 10.3389/fimmu.2025.1591944. eCollection 2025.
4
Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury.受新生儿启发对小胶质细胞全程序性细胞死亡进行重编程可增强成年脊髓损伤后的再生能力。
Research (Wash D C). 2025 Jul 2;8:0759. doi: 10.34133/research.0759. eCollection 2025.
5
Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study.血液代谢物作为勃起功能障碍的介质：来自多中心蛋白质组学和遗传学研究的见解
Front Pharmacol. 2025 Jun 2;16:1568780. doi: 10.3389/fphar.2025.1568780. eCollection 2025.
6
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.关键调节因子circPDE3B通过影响STAT3和NF-κB的稳定性促进砷诱导的膀胱癌发生。
Cell Biol Toxicol. 2025 May 28;41(1):91. doi: 10.1007/s10565-025-10038-2.
7
RIP2/NF-κB/PD-L1 signaling pathway is involved in temozolomide resistance by inducing autophagy in glioblastoma cells.RIP2/NF-κB/PD-L1信号通路通过诱导胶质母细胞瘤细胞自噬参与替莫唑胺耐药。
Transl Oncol. 2025 Aug;58:102424. doi: 10.1016/j.tranon.2025.102424. Epub 2025 May 22.
8
High expression of ITGB3 ameliorates asthma by inhibiting epithelial-mesenchymal transformation through suppressing the activation of NF-kB pathway.整合素β3（ITGB3）的高表达通过抑制核因子κB（NF-κB）途径的激活来抑制上皮-间质转化，从而改善哮喘。
Sci Rep. 2025 Apr 22;15(1):13837. doi: 10.1038/s41598-025-98842-y.
9
Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies.解码肿瘤血管生成：抗癌策略中的途径、机制及未来方向
Biomark Res. 2025 Apr 18;13(1):62. doi: 10.1186/s40364-025-00779-x.
10
Mechanism of salvianolic phenolic acids and hawthorn triterpenic acids combination in intervening atherosclerosis: network pharmacology, molecular docking, and experimental validation.丹酚酸与山楂三萜酸联合干预动脉粥样硬化的机制：网络药理学、分子对接及实验验证
Front Pharmacol. 2025 Jan 30;16:1501846. doi: 10.3389/fphar.2025.1501846. eCollection 2025.
本文引用的文献
1
Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer.靶向 NF-κB 诱导激酶（NIK）在免疫、炎症和癌症中的作用。
Int J Mol Sci. 2020 Nov 11;21(22):8470. doi: 10.3390/ijms21228470.
2
Polydeoxyribonucleotide Exerts Protective Effect Against CCl-Induced Acute Liver Injury Through Inactivation of NF-κB/MAPK Signaling Pathway in Mice.多聚脱氧核苷酸通过抑制 NF-κB/MAPK 信号通路对 CCl4 诱导的小鼠急性肝损伤发挥保护作用。
Int J Mol Sci. 2020 Oct 24;21(21):7894. doi: 10.3390/ijms21217894.
3
Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line.Hsp70 和 NF-kB 介导的犬巨噬细胞系固有炎症反应的控制。
Int J Mol Sci. 2020 Sep 4;21(18):6464. doi: 10.3390/ijms21186464.
4
Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor кb Activation in Preeclampsia.子痫前期中核因子 кb 激活的经典、非经典和非典型途径。
Int J Mol Sci. 2020 Aug 4;21(15):5574. doi: 10.3390/ijms21155574.
5
Small Molecule NF-κB Pathway Inhibitors in Clinic.小分子 NF-κB 通路抑制剂的临床应用
Int J Mol Sci. 2020 Jul 21;21(14):5164. doi: 10.3390/ijms21145164.
6
NF-κB and Its Role in Checkpoint Control.NF-κB 及其在检查点控制中的作用。
Int J Mol Sci. 2020 May 31;21(11):3949. doi: 10.3390/ijms21113949.
7
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View.NF-κB 能否被视为肿瘤疾病的有效药物靶点？我们的观点。
Int J Mol Sci. 2020 Apr 27;21(9):3070. doi: 10.3390/ijms21093070.
8
HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6.缺氧诱导因子-1β通过直接调控肿瘤坏死因子受体相关因子6正向调节核因子κB活性。
Int J Mol Sci. 2020 Apr 24;21(8):3000. doi: 10.3390/ijms21083000.
9
Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators.藜芦醇通过调节多种炎症介质缓解伽马辐射诱导的损伤。
Int J Mol Sci. 2020 Feb 6;21(3):1084. doi: 10.3390/ijms21031084.
10
Protective Effect of PBCA Nanoparticles Loaded with Thymulin Against the Relapsing-Remitting Form of Experimental Autoimmune Encephalomyelitis in Mice.载胸腺肽β4 聚氰基丙烯酸正丁酯纳米粒对实验性自身免疫性脑脊髓炎复发缓解型的保护作用。
Int J Mol Sci. 2019 Oct 29;20(21):5374. doi: 10.3390/ijms20215374.
Zotero 插件