School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, Australia.
School of Dentistry, The University of Queensland, Herston 4006, Australia.
Biointerphases. 2020 Dec 4;15(6):061010. doi: 10.1116/6.0000687.
Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evaluate the lifetime of the introduced surface layer, which is an important aspect affecting how a biomaterial will interact with a cellular environment both in the short and in the long term. This study evaluated the surface layer stability in vitro in buffer solution of materials produced from poly(lactic-co-glycolic acid) (50:50) and polycaprolactone modified by hydrolysis and/or grafting of hydrophilic polymers using grafting from approaches. The data presented in this study highlight the shortcomings of using model substrates (e.g., spun-coated films) rather than disks, particles, and scaffolds. It also illustrates how similar surface modification strategies in some cases result in very different lifetimes of the surface layer, thus emphasizing the need for these studies as analogies cannot always be drawn.
生物材料的表面修饰是一种用于改善细胞和体内结果的策略。然而，大多数研究都没有评估引入的表面层的寿命，这是一个重要的方面，它会影响生物材料在短期和长期内与细胞环境的相互作用。本研究评估了使用从接枝方法水解和/或接枝亲水聚合物改性的聚（乳酸-共-乙醇酸）（50:50）和聚己内酯材料在缓冲溶液中的体外表面层稳定性。本研究中提供的数据突出了使用模型底物（例如，旋涂薄膜）而不是圆盘、颗粒和支架的缺点。它还说明了在某些情况下，类似的表面修饰策略如何导致表面层的寿命非常不同，因此强调了进行这些研究的必要性，因为不能总是进行类比。
