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酵母小核RNA是核糖体前体RNA正常加工所必需的。

A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA.

作者信息

Tollervey D

机构信息

Génie Microbiologique, Institut Pasteur, Paris, France.

出版信息

EMBO J. 1987 Dec 20;6(13):4169-75. doi: 10.1002/j.1460-2075.1987.tb02763.x.

DOI:10.1002/j.1460-2075.1987.tb02763.x
PMID:3327689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC553900/
Abstract

In Saccharomyces cerevisiae, seven snRNAs (snR3, 4, 5, 8, 9, 10 and 17) are retained in the nucleus under conditions in which nucleoplasmic RNAs are lost, and may be nucleolar. All of these snRNAs show properties consistent with hydrogen bonding to pre-ribosomal RNAs; snR5 and 8 with 20S pre-rRNA, snR3, 4, 10 and 17 with 35S pre-rRNA and snR9 with 20-35S RNA. Strains lacking snR10 are impaired in growth and specifically defective in the processing of 35S RNA. Processing is slowed, leading to 35S RNA accumulation and most cleavage occurs, not at the normal sites, but at sites which in wild-type strains are used for subsequent steps in rRNA maturation.

摘要

在酿酒酵母中，七种小核仁RNA（snR3、4、5、8、9、10和17）在核质RNA丢失的条件下保留在细胞核中，可能位于核仁。所有这些小核仁RNA都表现出与前核糖体RNA形成氢键的特性；snR5和8与20S前体rRNA结合，snR3、4、10和17与35S前体rRNA结合，snR9与20 - 35S RNA结合。缺乏snR10的菌株生长受损，在35S RNA加工方面存在特异性缺陷。加工过程减慢，导致35S RNA积累，并且大多数切割不是发生在正常位点，而是发生在野生型菌株中用于rRNA成熟后续步骤的位点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/28c3ec69d386/emboj00253-0293-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/987d27075fc3/emboj00253-0289-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/4ba81efd8f6a/emboj00253-0290-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/1275b81bf9b2/emboj00253-0290-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/d9dd099ad862/emboj00253-0291-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/201579209c8c/emboj00253-0292-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/b747614c928e/emboj00253-0292-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/28c3ec69d386/emboj00253-0293-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/987d27075fc3/emboj00253-0289-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/4ba81efd8f6a/emboj00253-0290-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/1275b81bf9b2/emboj00253-0290-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/d9dd099ad862/emboj00253-0291-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/201579209c8c/emboj00253-0292-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/b747614c928e/emboj00253-0292-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2646/553900/28c3ec69d386/emboj00253-0293-a.jpg

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Transcriptional control in the production of liver-specific mRNAs.肝脏特异性mRNA产生过程中的转录调控。
Cell. 1981 Mar;23(3):731-9. doi: 10.1016/0092-8674(81)90436-0.
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