Department of Infectious Diseases, Peking University First Hospital, Peking University Health Science Center, Beijing 100034, China.
Department of Infectious Diseases, Peking University First Hospital, Peking University Health Science Center, Beijing 100034, China.
Infect Genet Evol. 2021 Jan;87:104663. doi: 10.1016/j.meegid.2020.104663. Epub 2020 Dec 3.
Hepatitis B virus (HBV) infection is still a serious health threat worldwide. The outcomes of HBV infection consist of spontaneous HBV clearance and chronic HBV infection. Multiple factors contribute to the disparity of HBV infection outcomes, including host factors, viral factors and environmental factors. The present review comprehends the current researches mainly focusing on the relationships between genetic determinants, including single nucleotide polymorphisms (SNPs) and haplotypes, and susceptibility of HBV infection, namely chronic (persistent) HBV infection and HBV clearance. A number of determinants in the chromosomes, including mutations in human leukocyte antigens (HLAs), cytokines genes, toll-like receptors (TLRs), and other genes are related to the human susceptibility to HBV infection. Among the above variants, some of those in HLAs have been studied and replicated in multiple-ethnic populations and came to consistent conclusions, while some others are novel and need to be evaluated further.
乙型肝炎病毒 (HBV) 感染仍然是全球严重的健康威胁。HBV 感染的结局包括自发性 HBV 清除和慢性 HBV 感染。多种因素导致 HBV 感染结局的差异，包括宿主因素、病毒因素和环境因素。本综述主要综述了目前的研究，重点关注遗传决定因素（包括单核苷酸多态性 (SNP) 和单倍型）与 HBV 感染易感性（即慢性（持续性）HBV 感染和 HBV 清除）之间的关系。染色体上的一些决定因素，包括人类白细胞抗原 (HLA) 突变、细胞因子基因、Toll 样受体 (TLR) 和其他基因，与人类对 HBV 感染的易感性有关。在上述变异中，一些 HLA 中的变异已在多民族人群中进行了研究和复制，并得出了一致的结论，而另一些则是新的，需要进一步评估。
