Pan Zhenzhen, Song Yuning, Zhe Xiangyi, Zhang Qin, Yuan Shumei, Zhao Zhe, Dong Hongwei, Hu Jingru, Zhao Yu, Zhang Guomei, Pan Zemin, Zhang Shaoqiang
Blood Transfusion Department, The Fourth Division Hospital of Xinjiang Production and Construction Corps, Yining 835000, China.
Department of Clinical Laboratory, Friendship Hospital of Yili Kazak Autonomous Region of Xinjiang, Yining 835000, China.
Virus Res. 2025 Apr;354:199542. doi: 10.1016/j.virusres.2025.199542. Epub 2025 Feb 17.
Analyze the infection status of four blood-borne infectious diseases, namely hepatitis B, hepatitis C, syphilis, and acquired immune deficiency syndrome (AIDS), among pregnant women from different ethnic groups in Yili, Xinjiang. The objective is to assess the prevalence of four infectious diseases among pregnant women in this region and provide reference for the prevention and elimination of mother-to-child transmission. Pregnant women of Han and Uygur ethnicity who underwent prenatal screening at our outpatient clinic between 2016 and 2022 were selected for screening for hepatitis B virus surface antigen (HBsAg), antibody to hepatitis C virus (anti-HCV), antibody to treponema pallidum (anti-TP) and antibody to human immunodeficiency virus (anti-HIV) using an enzyme-linked immunosorbent assay (ELISA). A total of 13,437 pregnant women were tested, aged between 18 and 47. The positive rate of four infectious disease markers in Han and Uygur pregnant women in this region was 6.97 % (936/13,437). The total positive rate of HBsAg was 6.44 % (865/13,437), among which the Han women of HBsAg positive rate was 6.63 % (836/12,608), and the HBsAg positive rate in Uygur women was 3.63 % (29/829) (χ2=12.673, P = 0.000); the total positive rate of anti-HCV was 0.16 % (21/13,437), of which the anti-HCV positive rate of Han women was 0.15 % (19/12,608), and anti-HCV positive rate in Uygur women was 0.24 % (2/829). (χ2=0.034, P = 0.853); the total positive rate of anti-TP was 0.34 % (46/13,437), of which the positive rate of anti-TP in Han women was 0.24 % (30/12,608), and the positive rate of anti-TP in Uygur women was 1.93 % (16/829) (χ2=65.280, P = 0.000); the total positive rate of anti-HIV was 0.03 % (4/13,437), of which Han nationality anti-HIV positive rate was 0 % (0/12,608), and the anti-HIV positive rate in Uygur nationality was 0.48 % (4/829) (P = 0.000). The positive rate of hepatitis B surface antibodies (anti-HBs) positive in Han nationality was 56.44 % (7116/12,608) and the positive rate of anti-HBs in Uygur nationality was 41.62 % (345/829) (χ2=65.219, P = 0.000); the all-negative detection rate of Han nationality was 29.04 % (3661/12,608) and the Uygur nationality of all-negative detection rate was 46.20 % (383/829) (χ2=104.352, P = 0.000). Our results suggest that the difference in infection rates between Han and Uygur pregnant women in Yili, Xinjiang, may be related to the different genetic susceptibility among different ethnic groups.
分析新疆伊犁不同民族孕妇中乙型肝炎、丙型肝炎、梅毒和获得性免疫缺陷综合征（艾滋病）这四种血源性传染病的感染状况。目的是评估该地区孕妇中四种传染病的流行情况，为预防和消除母婴传播提供参考。选取2016年至2022年期间在我院门诊进行产前检查的汉族和维吾尔族孕妇，采用酶联免疫吸附试验（ELISA）检测乙肝病毒表面抗原（HBsAg）、丙型肝炎病毒抗体（抗-HCV）、梅毒螺旋体抗体（抗-TP）和人类免疫缺陷病毒抗体（抗-HIV）。共检测13437名孕妇，年龄在18至47岁之间。该地区汉族和维吾尔族孕妇四种传染病标志物的阳性率为6.97%（936/13437）。HBsAg总阳性率为6.44%（865/13437），其中汉族女性HBsAg阳性率为6.63%（836/12608），维吾尔族女性HBsAg阳性率为3.63%（29/829）（χ2 = 12.673，P = 0.000）；抗-HCV总阳性率为0.16%（21/13437），其中汉族女性抗-HCV阳性率为0.15%（19/12608），维吾尔族女性抗-HCV阳性率为0.24%（2/829）。（χ2 = 0.034，P = 0.853）；抗-TP总阳性率为0.34%（46/13437），其中汉族女性抗-TP阳性率为0.24%（30/12608），维吾尔族女性抗-TP阳性率为1.93%（16/829）（χ2 = 65.280，P = 0.000）；抗-HIV总阳性率为0.03%（4/13437），其中汉族抗-HIV阳性率为0%（0/12608），维吾尔族抗-HIV阳性率为0.48%（4/829）（P = 0.000）。汉族乙肝表面抗体（抗-HBs）阳性率为56.44%（7116/12608），维吾尔族抗-HBs阳性率为41.62%（345/829）（χ2 = 65.219，P = 0.000）；汉族全阴性检测率为29.04%（3661/12608），维吾尔族全阴性检测率为46.20%（383/829）（χ2 = 104.352，P = 0.000）。我们的结果表明，新疆伊犁汉族和维吾尔族孕妇感染率的差异可能与不同民族间遗传易感性不同有关。
