Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Madrid, Spain; Rudjer Boskovic Institute, Division of Molecular Medicine, Laboratory for Molecular Neuropsychiatry, Zagreb, Croatia.
Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Madrid, Spain.
J Pharm Biomed Anal. 2021 Feb 5;194:113681. doi: 10.1016/j.jpba.2020.113681. Epub 2020 Nov 21.
Gut microbiota represents a complex physiological ecosystem that influences the host health. Alterations in the microbiome metabolism affect the body homeostasis and they have been associated with the development of different human neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease, autism spectrum disorder, bipolar disorder, depression, Huntington's disease, Parkinson's disease, posttraumatic stress disorder and schizophrenia. The development of these complex diseases is influenced by various factors, including genetic predisposition and environmental triggers. Gut microbiota has recently emerged as an important actor in their physiopathology that has been shown to play a role in inflammation, oxidative stress, and gut permeability. Therefore, targeting the metabolites that are produced by or associated with the gut microbiota may help us understand how imbalance in the gut-brain axis affects human health. This review offers a comprehensive overview of the literature on this matter, offering the readers an insight in the state-of-art metabolic measurements of the gut-brain axis in various brain-related diseases.
肠道微生物群代表了一个复杂的生理生态系统，影响着宿主的健康。微生物群代谢的改变会影响身体的动态平衡，并且与不同的人类神经退行性和神经精神疾病的发展有关，如阿尔茨海默病、自闭症谱系障碍、双相情感障碍、抑郁症、亨廷顿病、帕金森病、创伤后应激障碍和精神分裂症。这些复杂疾病的发展受到多种因素的影响，包括遗传易感性和环境触发因素。肠道微生物群最近作为其病理生理学中的一个重要因素出现，它被证明在炎症、氧化应激和肠道通透性中发挥作用。因此，针对由肠道微生物群产生或与之相关的代谢物可能有助于我们了解肠道-大脑轴的失衡如何影响人类健康。这篇综述对这方面的文献进行了全面概述，为读者提供了在各种与大脑相关的疾病中对肠道-大脑轴进行代谢测量的最新技术。
