风湿热和风湿性心脏病患者抗A组链球菌多糖抗体滴度
Antibody titer to group A streptococcal polysaccharide in rheumatic fever and rheumatic heart disease.
作者信息
Fujikawa S, Ohkuni M, Lue H C
机构信息
Department of Pediatrics, Dokkyo Medical School, Koshigaya Hospital, Japan.
出版信息
Jpn Circ J. 1987 Dec;51(12):1347-9. doi: 10.1253/jcj.51.1347.
Antibody to group A streptococcal polysaccharide (ASP) is the only antibody of cellular components which is now detectable in clinical practice. Streptococcal polysaccharide is known to have cross-immunity with the glycoprotein of human heart tissue, and has been discussed as a pathogenesis of rheumatic carditis and valvular heart disease. In this study, ASP titer was determined by passive hemagglutination technique in patients with rheumatic fever and rheumatic heart disease. ASP titer showed higher levels in these patients compared to control children, but there was no specificity in rheumatic carditis or rheumatic heart disease.
抗A组链球菌多糖（ASP）抗体是目前临床实践中唯一可检测到的细胞成分抗体。已知链球菌多糖与人心脏组织的糖蛋白具有交叉免疫性，并被认为是风湿性心肌炎和心脏瓣膜病的发病机制之一。在本研究中，采用被动血凝技术测定了风湿热和风湿性心脏病患者的ASP滴度。与对照儿童相比，这些患者的ASP滴度更高，但在风湿性心肌炎或风湿性心脏病中并无特异性。
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