Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
Int J Pharm. 2021 Jan 25;593:120141. doi: 10.1016/j.ijpharm.2020.120141. Epub 2020 Dec 3.
Functional peptides that are made up of diverse endogenous amino acids with a specific sequence and length have shown various functionalities including specific biological recognition and cell penetrating ability for biomedical applications. Therefore, incorporation of peptide with a certain tailor-made amino acid sequence to the delivery systems has endowed the resulting delivery vehicles with specific functions, which provided a robust strategy for enhancing the therapeutic efficiency for malignant diseases. To make a timely review on this hot subject of research, we summarized the recent progress on peptide-functionalized delivery vehicles for enhanced cancer therapy with an emphasis on the chemistry adopted for the conjugation of peptide compared to most of the published reviews with a focus on the property and performance of the peptide-functionalized delivery systems. The primary synthetic strategies used for peptide conjugation were first summarized. An exhibition of four different types of peptide-functionalized delivery vehicles were next presented following a classification standard of the functions of each peptide category including tumor-targeting peptide, cell-penetrating peptide, subcellular organelle-targeting peptide and tumor-penetrating peptide. A concluding remark on the future direction of this rapidly developing research field was made finally. The important principles on the design of peptide, screening of the conjugation strategy, and optimization of peptide property that were drawn from the detailed comparison of the representative literature in this review will provide useful guidelines for the future development of advanced peptide-functionalized delivery platforms with enhanced therapeutic efficiency for cancer therapy.
具有特定序列和长度的不同内源性氨基酸组成的功能肽表现出多种功能，包括生物特异性识别和细胞穿透能力，可应用于生物医学。因此，将具有特定氨基酸序列的肽掺入到递药系统中，使所得的递药载体具有特定的功能，为提高恶性疾病的治疗效果提供了强有力的策略。为了及时回顾这一热门研究课题，我们总结了最近在肽功能化递药系统用于增强癌症治疗方面的进展，重点介绍了与大多数已发表的综述相比，用于肽键合的化学方法，这些综述主要关注肽功能化递药系统的性质和性能。首先总结了用于肽键合的主要合成策略。接下来，根据每种肽类的功能（包括肿瘤靶向肽、细胞穿透肽、亚细胞器靶向肽和肿瘤穿透肽）进行分类，展示了四种不同类型的肽功能化递药载体。最后对这一快速发展的研究领域的未来方向作了总结。从本综述中代表性文献的详细比较中得出的关于肽设计、键合策略筛选和肽性质优化的重要原则，将为具有增强癌症治疗效果的先进肽功能化递药平台的未来发展提供有用的指导。
