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登革热和 COVID-19 双重感染病例报告:婴儿多器官功能障碍表现。

A Case Study of Dual Infection of Dengue and COVID-19: Presenting as Multiorgan Dysfunction in an Infant.

机构信息

Department of Pediatrics, Medical College Kolkata, Kolkata 700073, West Bengal, India.

Department of Pediatrics, Institute of Child Health, Kolkata 700017, West Bengal, India.

出版信息

J Trop Pediatr. 2021 Jan 29;67(1). doi: 10.1093/tropej/fmaa080.

Abstract

Dengue is a major health concern in South Asian countries transmitted by bite of day breeder mosquitoes Aedes aegypti and Aedes albopictus. Severity of plasma leak, shock, bleeding tendency and other organ dysfunction can be more pronounced in infants. The management becomes further complicated in the presence of a co-existing COVID-19 infection. Although COVID-19 infection is usually asymptomatic or has mild manifestations in children, however in presence of serious co-infection like dengue it can modify the course of the illness and lead to drastic consequences. Here, we present one such case of a 9-month-old female child who tested positive for dengue as well as COVID-19 during the ongoing corona pandemic and went on to develop shock, encephalopathy with deranged liver enzymes but managed to overcome all odds and recover from the disease by day 14 of illness.

摘要

登革热是南亚国家的一个主要卫生问题,由白纹伊蚊和埃及伊蚊等日间繁殖的蚊子叮咬传播。婴儿可能出现更严重的血浆渗漏、休克、出血倾向和其他器官功能障碍。如果同时存在 COVID-19 感染,管理会变得更加复杂。虽然 COVID-19 感染在儿童中通常无症状或表现为轻症,但在严重合并感染如登革热的情况下,它可能会改变疾病进程并导致严重后果。在这里,我们介绍了一个这样的病例,一名 9 个月大的女婴在当前的新冠疫情期间同时检测出登革热和 COVID-19 呈阳性,继而发展为休克、伴有肝酶异常的脑病,但通过第 14 天的治疗,她成功克服了所有困难并从疾病中康复。

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Co-infection of dengue and COVID-19: A case report.登革热与新型冠状病毒肺炎合并感染:一例病例报告。
PLoS Negl Trop Dis. 2020 Aug 3;14(8):e0008476. doi: 10.1371/journal.pntd.0008476. eCollection 2020 Aug.
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Multisystem Inflammatory Syndrome in U.S. Children and Adolescents.美国儿童和青少年中的多系统炎症综合征。
N Engl J Med. 2020 Jul 23;383(4):334-346. doi: 10.1056/NEJMoa2021680. Epub 2020 Jun 29.
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Hyperinflammatory shock in children during COVID-19 pandemic.新冠疫情期间儿童的高炎症性休克
Lancet. 2020 May 23;395(10237):1607-1608. doi: 10.1016/S0140-6736(20)31094-1. Epub 2020 May 7.

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