Deparment of Neurology Manisa, Celal Bayar University, Manisa, Turkey.
Int J Neurosci. 2022 Oct;132(10):999-1004. doi: 10.1080/00207454.2020.1860036. Epub 2020 Dec 30.
Acute respiratory syndrome coronavirus-2 (Covid-19) can infect the respiratory system, as well as the central, peripheral nervous system, and muscles, leading to neurological symptoms and signs. The most common neurological symptoms are dizziness, headache, impaired consciousness, ataxia, hypogosis, hyposmia, neuralgia, and myalgia. The most common neurological diseases are acute cerebrovascular disease, epilepsy, acute hemorrhagic necrotizing encephalopathy, miyelitis, and Gullian-Barre syndrome.
In this case report, a patient infected with Covid-19 and diagnosed as neuromyelitis optica (NMO) with anamnesis, clinical and radiological findings is presented.
A 50-year-old woman presented with weakness of both legs, urine retention, high fever, and cough. Spinal magnetic resonance imaging revealed expensive long-segment and centrally located demyelinating lesion extending from the cervical cord (at the level of C3) to the conus. Thoracic-computerized tomography revealed consolidation areas located on the lower segments of bilateral lungs and ground-glass density, air bronchograms, and peribronchial thickening surrounding these areas. Aquaporin-4 immune globulin-G was found to be positive.
It was considered appropriate to present this case because of being the first case of parainfectious NMO considered to be induced by SARS-CoV-2.
严重急性呼吸综合征冠状病毒 2 型(Covid-19)可感染呼吸系统以及中枢、周围神经系统和肌肉,导致神经系统症状和体征。最常见的神经系统症状是头晕、头痛、意识障碍、共济失调、昏睡、嗅觉减退、神经痛和肌痛。最常见的神经系统疾病是急性脑血管病、癫痫、急性出血性坏死性脑病、脊髓炎和吉兰-巴雷综合征。
本病例报告介绍了一位有新冠病毒感染史的患者,被诊断为视神经脊髓炎(NMO),具有病史、临床和影像学发现。
一位 50 岁女性,表现为双下肢无力、尿潴留、高热和咳嗽。脊髓磁共振成像显示昂贵的长节段和中央位于颈髓(C3 水平)至圆锥的脱髓鞘病变。胸部计算机断层扫描显示位于双肺下叶的实变区和磨玻璃密度,伴有空气支气管征,这些区域周围有支气管周围增厚。发现水通道蛋白 4 免疫球蛋白-G 呈阳性。
考虑到这是首例被认为由 SARS-CoV-2 引起的副感染性 NMO 病例,因此提出这个病例是合适的。