MHC Ⅲ 类 RNA 结合蛋白与免疫。
MHC Class III RNA Binding Proteins and Immunity.
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Biochemistry and Molecular Biology Graduate Program, University of Texas Medical Branch, Galveston, Texas, USA.
出版信息
RNA Biol. 2021 May;18(5):640-646. doi: 10.1080/15476286.2020.1860388. Epub 2020 Dec 20.
Abstract
Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, , encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.
摘要
在这里，我们回顾了 RNA 结合蛋白在脊椎动物免疫中作用的相关数据。我们重点关注了主要组织相容性复合体 III 类区域中发现的基因产物。其中 6 个基因编码 RNA 结合蛋白，这些蛋白在转录后基因调控和 RNA 监测中具有明确的作用。这些基因很可能在免疫中具有重要功能，并与自身免疫性疾病相关。
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