Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Institute of Pharmacy, VBS Purvanchal University, Jaunpur, Uttar Pradesh, India.
Recent Pat Drug Deliv Formul. 2020;14(3):214-222. doi: 10.2174/1872211314666201204160641.
The manuscript aims to describe the techniques of modification of gums and mucilages and their effect on hydrophilicity and drug release.
The interest is increased in the fields of polymers which are obtained from natural origin and used in the preparation of pharmaceuticals. Mucilage and gum are natural materials widely used in the preparation of novel dosage and conventional dosage forms. They are used in the pharmaceutical industry for various purposes like suspending, emulsifying, bio-adhesive, binding, matrix-forming, extended release and controlled release agent. Gum and mucilage are biodegradable, less toxic, cheap and easily available. Moreover, mucilage and gum can be changed to acquire tailored materials for the delivery of drugs and allow them to compete with commercially available synthetic products. These polysaccharides have unique swellability in an aqueous medium that can exert a retardant effect on drug release or act as a super disintegrant, depending on the concentration utilized in the preparation. Drug release mechanism from hydrophilic matrices consisting of gums and mucilages is based on solvent penetration-induced polymer relaxation, diffusion of entrapped drug followed by degradation or erosion of the matrix.
The present manuscript highlights the advantages, modifications of gum and mucilage, their effects on hydrophilicity and drug release as well as aspects of the natural gums which can be assumed to be bifunctional excipient because of their concentration-dependent effect on drug release and their high degree of swellability.
本文旨在描述胶和黏液的修饰技术及其对亲水性和药物释放的影响。
人们对来源于天然的聚合物领域越来越感兴趣，这些聚合物被用于药物制剂的制备。黏液和胶是天然材料，广泛用于新型和传统制剂形式的制备。它们在制药行业中用于各种用途，如悬浮、乳化、生物黏附、黏合、基质形成、延长释放和控制释放剂。胶和黏液是可生物降解的、毒性较低、便宜且容易获得的。此外，胶和黏液可以进行改性，以获得用于药物传递的定制材料，并使它们能够与市售的合成产品竞争。这些多糖在水介质中有独特的溶胀性，根据在制剂中使用的浓度，可以对药物释放产生延迟作用或充当超级崩解剂。由胶和黏液组成的亲水性基质中的药物释放机制基于溶剂渗透诱导的聚合物松弛、包封药物的扩散，随后是基质的降解或侵蚀。
本文重点介绍了胶和黏液的优点、改性、对亲水性和药物释放的影响，以及天然胶的一些方面，由于其对药物释放的浓度依赖性影响和高度的溶胀性，天然胶可以被认为是一种双功能赋形剂。
